| MAD | major affective disorder; mandibulo-acral dysplasia; maximum allowable dose; methylandrostenediol; m... |
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| MED | median erythrocyte diameter; medical, medication, medicine; Medical Entities Dictionary; minimum eff... |
| MHD | maintenance hemodialysis; mean hemolytic dose; mental health department; minimum hemolytic dilution;... |
| MLD | manual lymph drainage; median lethal dose; metachromatic leukodystrophy; minimal lesion disease; min... |
| MPD | main pancreatic duct; maximum permissible dose; mean population doubling; membrane potential differe... |
| dose-effect curve | This is a graph drawn to show the relationship between the dose of a drug or other chemical and the magnitude of the graded effect that it produces. (09 Oct 1997) |
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| dose-escalation | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |
| dose fractionation | Adminstration of the total dose of radiation (radiation dosage) in parts, at timed intervals. (12 Dec 1998) |
| dose intensity | In chemotherapy, the total amount of drug delivered in a one-week period. Can be given all at once or over a period of several days. (16 Dec 1997) |
| dose-ranging | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |
| dose-response curve | This is a graph to show the relation between the dose of a drug or other chemical and the degree of response it produces, as measured by the percentage of the exposed population showing a defined, often quantal, effect. (09 Oct 1997) |
| dose-response relationship | Relationship in which a change in the amount, intensity, or duration of exposure is associated with a change in risk of a specified outcome. (05 Mar 2000) |
| dose-response relationship, drug | The relationship between the dose of an administered drug and the response of the organism to the drug. (12 Dec 1998) |
| dose-response relationship, immunologic | A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. (12 Dec 1998) |
| dose-response relationship, radiation | The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. (12 Dec 1998) |
| initial dose | A comparatively large dose given at the beginning of treatment to get the patient under the influence of the drug. Synonym: loading dose. (05 Mar 2000) |
| integral dose | The total energy absorbed by the body, the product of the mass of tissue irradiated and the absorbed dose; unit, the gram rad. (05 Mar 2000) |
| optimum dose | The dose of a drug or radiation that will produce the desired effect with minimum likelihood of undesirable symptoms. (05 Mar 2000) |
| therapeutic dose | The quantity of any substance required to effect the cure of a disease or that will correct the manifestations of a deficiency of a particular factor in the diet, effective dose used with therapeutically applied compounds. Synonym: therapeutic dose. (05 Mar 2000) |
| effective dose | The dose that produces the desired effect; when followed by a subscript (generally "ED50"), it denotes the dose having such an effect on a certain percentage (e.g., 50%) of the test animals; ED50 is the median effective dose, in radiation protection, the sum of the equivalent doses in all tissues and organs of the body weighted for tissue effects of radiation. The unit of effective dose is the sievert (Sv), epilation dose, the minimum amount of radiation sufficient to produce hair loss, usually in 10 to 14 days. (05 Mar 2000) |