| kininogen, high-molecular-weight | A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with prekallikrein. Hmwk is split by plasma kallikrein to produce bradykinin. The complex is a cofactor in the activation of coagulation factor xii. The product of this reaction, xiia, in turn activates prekallikrein to kallikrein. (12 Dec 1998) |
|---|---|
| kininogen, low-molecular-weight | A protein, molecular weight 50 kD, located in various normal tissues. Upon cleavage by kallikrein or other kallikreins, it forms kallidin. Kallidin, in turn, is converted into bradykinin. (12 Dec 1998) |
| kininogenase | <protein> Plasma serine proteases normally present as inactive prekallikreins which are activated by Hageman factor. Act on kininogens to produce kinins. Contain an apple domain. (18 Nov 1997) |
| kininogenin | <protein> Plasma serine proteases normally present as inactive prekallikreins which are activated by Hageman factor. Act on kininogens to produce kinins. Contain an apple domain. (18 Nov 1997) |
| kininogens | <chemical> Endogenous peptides present in most body fluids. Certain enzymes convert them to active kinins which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. High-molecular-weight kininogen (hmwk) is split by plasma kallikrein to produce bradykinin. Low-molecular-weight kininogen (lmwk) is split by tissue kallikrein to produce kallidin. Pharmacological action: cysteine proteinase inhibitors. (12 Dec 1998) |
| kinins | <biochemistry> Inflammatory mediators that cause dilation of blood vessels and altered vascular permeability. Kinins are small peptides produced from kininogen by kallikrein and are broken down by kininases. Act on phospholipase and increase arachidonic acid release and thus prostaglandin (PGE2) production. See: bradykinin, kallidin, C2 kinin. (18 Nov 1997) |
| kink | An angulation, bend, or twist. (05 Mar 2000) |
| kinkajou | <zoology> A nocturnal carnivorous mammal (Cercoleptes caudivolvulus) of South America, about as large as a full-grown cat. It has a prehensile tail and lives in trees. It is the only representative of a distinct family (Cercoleptidae) allied to the raccoons. Synonym: potto, and honey bear. Origin: F. Kinkajou, quincajou, from the native American name. Source: Websters Dictionary (01 Mar 1998) |
| kinked aorta | Distortion, often with slight narrowing, of the aortic arch at the level of insertion of the ligamentum arteriosum. Synonym: buckled aorta, kinked aorta. (05 Mar 2000) |
| Kinkiang fever | Schistosomiasis caused by schistosoma japonicum. It is endemic in the far east and affects the bowel, liver, and spleen. (12 Dec 1998) |
| kinky hair | Tightly curled or bent hair. See: kinky-hair disease. (05 Mar 2000) |
| kinky hair syndrome | <syndrome> Genetic disorder with fragile twisted ( kinky ) hair and progressive deterioration of the brain. Due to an error in copper transport resulting in copper deficiency. Females are carriers and their sons with the gene have the disease. Also known as menkes syndrome. (12 Dec 1998) |
| kinky-hair disease | Kinky hair disease, congenital defect of copper metabolism manifested in short, sparse, poorly pigmented kinky hair; associated with failure to thrive, physical and mental retardation, and progressive severe deterioration of the brain; apparently a defect of copper transport; X-linked recessive inheritance. Synonym: kinky-hair disorder, Menkes' syndrome, trichopoliodystrophy. (05 Mar 2000) |
| kinky-hair disorder | Kinky hair disease, congenital defect of copper metabolism manifested in short, sparse, poorly pigmented kinky hair; associated with failure to thrive, physical and mental retardation, and progressive severe deterioration of the brain; apparently a defect of copper transport; X-linked recessive inheritance. Synonym: kinky-hair disorder, Menkes' syndrome, trichopoliodystrophy. (05 Mar 2000) |
| kinnikinic | Prepared leaves or bark of certain plants; used by the Indians of the Northwest for smoking, either mixed with tobacco or as a substitute for it. Also, a plant so used, as the osier cornel (Cornus stolonijra), and the bearberry (Arctostaphylus Uva-ursi). [Spelled also kinnickinnick and killikinick. Origin: Indian, literally, a mixture. Source: Websters Dictionary (01 Mar 1998) |