| TCID50 | median tissue culture infective dose; 50% tissue culture infective dose |
|---|---|
| TDF | testis-determining factor; thoracic duct fistula; thoracic duct flow; time-dose fractionation; tissu... |
| TDI | temperature difference integration; three-dimensional interlocking [hip]; toluene 2,4-diisocyanate; ... |
| HL | Half Life |
| HVL | Half-Value Layer |
| fractional dose | A definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually one day. Synonym: fractional dose. (05 Mar 2000) |
|---|---|
| L+ dose | The limes tod dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, results in death of the animal within 96 hours (based on the average in a series); on theoretical grounds, one might expect that the difference between the L+ and L0 dose's would be identical to 1 MLD, but this is not so in actual practice; with various toxic filtrates, the difference may range from several to more than 100 MLD's, indicating that the toxin-antitoxin combination is not a firm chemical union that occurs in constant proportions. (05 Mar 2000) |
| Lf dose | The limes flocculation dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin, yields the most rapid flocculation in the Ramon test (in vitro); in general, the Lf dose is slightly less than the Lr dose. (05 Mar 2000) |
| loading dose | <pharmacology> A quantity higher than the average or maintenance dose, used at the initiation of therapy to rapidly establish a desired level of the drug (18 Nov 1997) |
| Lo dose | <pharmacology> The limes nul dose of diphtheria toxin, i.e., the largest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, yields no recognizable reaction in the average of a series; actually, the Lod. Is usually recorded as the one that causes a barely perceptible local oedema at the site of inoculation. (05 Mar 2000) |
| Lr dose | The limes reacting dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin and injected intracutaneously in the shaved skin of a susceptible guinea pig, yields a minimal, positive reaction and inflammation localised to the region of the injection; the Lrd. Closely approximates the Lod., as would be expected, inasmuch as a slight excess of unneutralised toxin results in a reaction. (05 Mar 2000) |