| pregnancy proteins | Proteins produced by organs of the mother or the placenta during pregnancy. They may be either pregnancy specific (present only during pregnancy) or pregnancy associated (always present during pregnancy, but may also be present in individuals undergoing oestrogen therapy, taking oral contraceptives or in patients with certain malignancies.) (12 Dec 1998) |
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| pregnancy zone proteins | Glycoproteins with the electrophoretic mobility of an alpha 2-globulin. They are found in small amounts in normal human plasma but in much larger volume in the plasma of pregnant women. These proteins have also been found in increased amounts in individuals undergoing oestrogen therapy and are sometimes produced ectopically by tumours of non-placental origin. Pregnancy zone proteins are believed to be of maternal rather than placental origin. (12 Dec 1998) |
| cytoskeletal proteins | Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible. (12 Dec 1998) |
| heat-shock proteins 70 | <cell biology, protein> A class of molecular chaperones found in both prokaryotes and in several compartments of eukaryotic cells. There is evidence that these proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures. (12 Dec 1998) |
| heat-shock proteins 90 | <cell biology, protein> A class of molecular chaperones whose members act in the mechanism of signal transduction by steroid receptors. (12 Dec 1998) |
| salivary proteins | Proteins found in saliva and the salivary glands. These proteins show some enzymatic activity, but their composition varies in different individuals. (12 Dec 1998) |
| helminth proteins | Proteins found in any species of helminth. (12 Dec 1998) |
| scaffold proteins | Proteins that remain when chromosomes are digested with DNase. Many antigenic species have been identified. (18 Nov 1997) |
| proteins | Nitrogenous organic compounds, containing more than about 100 amino acid residues, molecular weight 8,000-200,000, in vegetable and animal matter. Proteins yield amino acids on hydrolysis and are foods assimilated as amino acids and reconstructed in the protoplasm. (12 Dec 1998) |
| proto-oncogene proteins | Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. (12 Dec 1998) |
| proto-oncogene proteins c-abl | Membrane proteins encoded by the c-abl genes. They exhibit tyrosine kinase activity and play a role in normal haematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific n-terminal amino acids are deleted, releasing the kinase from negative regulation. (12 Dec 1998) |
| proto-oncogene proteins c-bcl-2 | Membrane proteins encoded by the bcl-2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are found on mitochondrial, microsomal, and nuclear membrane sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (12 Dec 1998) |
| proto-oncogene proteins c-erbb-2 | Cellular proteins in the epidermal growth factor receptor family encoded by the c-erbb genes. These proteins are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression. (12 Dec 1998) |
| proto-oncogene proteins c-fos | Cellular DNA-binding proteins encoded by the c-fos genes (genes, fos). They are involved in growth-related transcriptional control. C-fos combines with c-jun (proto-oncogene proteins c-jun) to form a c-fos/c-jun heterodimer (transcription factor ap-1) that binds to the tre (tpa-responsive element) in promoters of certain genes. (12 Dec 1998) |
| proto-oncogene proteins c-jun | Cellular DNA-binding proteins encoded by the c-jun genes (genes, jun). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun. (12 Dec 1998) |