| diffuse small cleaved cell lymphoma | <tumour> A diffuse poorly differentiated lymphocytic lymphoma; follicular centre cell lymphoma that lacks a follicular pattern; malignancy is of intermediate grade. (05 Mar 2000) |
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| diffuse waxy spleen | A condition of amyloid degeneration of the spleen, affecting chiefly the extrasinusoidal tissue spaces of the pulp. Synonym: lardaceous spleen (05 Mar 2000) |
| oesophageal spasm, diffuse | A motor disorder of the oesophagus characterised by chest pain and dysphagia. Pathogenesis is unclear. Strong, nonpropulsive contractions of the oesophagus evoked by deglutition occur, especially in the elderly. (12 Dec 1998) |
| keratoderma, palmoplantar, diffuse | An autosomal dominant disorder characterised by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (keratoderma, palmoplantar), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present. (12 Dec 1998) |
| leishmaniasis, diffuse cutaneous | A form of leishmaniasis, cutaneous caused by leishmania aethiopica in ethiopia and kenya, l. Pifanoi in venezuela, l. Braziliensis in south america, and l. Mexicana in central america. This disease is characterised by massive dissemination of skin lesions without visceral involvement. (12 Dec 1998) |
| leukodystrophy with diffuse Rosenthal fibre formation | A metabolic disorder whose onset can be in infancy, adolescence, or adulthood; characterised pathologically by widespread cerebral demyelination with astrocyte and primitive oligodendroglial cell proliferation; refractile Rosenthal fibres result from the degeneration of these proliferating cells; aetiology unknown, but possibly due to a metabolic defect of astrocytes; sex-linked recessive disorder. (05 Mar 2000) |
| lymphoma, diffuse | Malignant lymphoma in which neoplastic cells diffusely infiltrate the entire lymph node without any definite organised pattern. Patients whose lymphomas present a diffuse pattern generally have a more unfavorable survival outlook than those presenting with a follicular or nodular pattern. (12 Dec 1998) |
| lymphoma, large-cell, diffuse | Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (12 Dec 1998) |
| lymphoma, mixed-cell, diffuse | A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases. (12 Dec 1998) |
| lymphoma, small cleaved-cell, diffuse | An intermediate-grade malignant lymphoma in which the neoplastic cells (B-lymphocytes) exhibit variability in size, configuration, and degree of differentiation. The cells have distinctive nuclei, irregular in shape, with marked indentations and angularity. (12 Dec 1998) |