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closed circuit anesthesia inhalation anesthesia maintained by the continuous rebreathing of a relatively small amount of anesthetic gas and a basal amount of oxygen, normally used with an absorption apparatus for the removal of carbon dioxide.
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closed loop reflex a reflex, such as a stretch reflex, in which the stimulus (such as muscle stretch) decreases when it receives feedback from the response mechanism.
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closing capacity the volume of gas in the lungs at the time the airways close during respiration; the closing volume added to the residual volume, usually expressed as a percentage of total lung capacity.
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Clostridium histolyticum collagenase any of several forms of microbial collagenase isolated from Clostridium histolyticum that catalyze the cleavage of collagen into small fragments, cleaving it in the triple helical region N-terminal to glycine residues. The extracellular Zn 2 + enzyme degrades the collagen framework of muscles, facilitating the spread of gas gangrene by C. histolyticum.
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closed comedo a comedo whose opening is not widely dilated, appearing as a small, flesh-colored papule; because the keratin and sebum produced cannot escape, it may rupture and cause an inflammatory lesion in the dermis. Called also whitehead.
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