| central complex | In an enzyme-catalyzed reaction, the structural complex of the enzyme and all of the enzyme's substrates (or the enzyme with all of the enzyme's products) equivalent to the binary complex for a one-substrate enzyme. Compare: binary complex, Michaelis complex. (05 Mar 2000) |
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| central cord syndrome | <syndrome> Quadriparesis most severely involving the distal upper extremities, with or without sensory loss and bladder dysfunction, usually due to ischemia from osteophytic or traumatic compression of the central part of the cervical spinal cord and/or artery. (05 Mar 2000) |
| central core disease | A congenital myopathy characterised by hypotonia, delay of motor development in infancy, and nonprogressive or slowly progressive muscle weakness; on biopsy the central core of muscle fibres stains abnormally, myofibrils are abnormally compact, and there is virtual absence of mitochondria and sarcoplasmic reticulum; histochemically, the cores are devoid of oxidative enzyme, phosphorylase, and ATPase activity; autosomal dominant inheritance, often subclinical. (05 Mar 2000) |
| central core disease of muscle | <neurology> One of the conditions that produces floppy baby syndrome. It causes hypotonia (floppiness) in the newborn baby, slowly progressive muscle weakness, and muscle cramps after exercise. Muscle biopsy shows a key diagnostic finding (absent mitochondria in the centre of many type I muscle fibres). The disease is inherited as a dominant trait. The CCD gene is on chromosome 19 (and involves ryanodine receptor-1). Inheritance: autosomal dominant. (12 Dec 1998) |
| central deafness | Deafness due to disorder of the auditory system of the brainstem or cerebral cortex. (05 Mar 2000) |
| central dogma | <molecular biology> The main principle of molecular biology, coined by Francis Crick, which states that genetic information flows from DNA to RNA to protein. (09 Oct 1997) |
| Central European tick-borne encephalitis virus | One of the virus's of the tick-borne encephalitis complex of group B arboviruses (genus Flavivirus); the causative agent of tick-borne encephalitis (Central European subtype). (05 Mar 2000) |
| Central European tick-borne fever | 1. (Central European subtype) tick-borne meningoencephalitis caused by a flavivirus closely related to the virus causing the Far Eastern type; it is transmitted by Ixodes ricinus, also by infected raw milk, especially that of goats. Synonym: biundulant meningoencephalitis, Central European tick-borne fever, diphasic milk fever, Russian spring-summer encephalitis (Western subtype). 2. (Eastern subtype) tick-borne encephalitis, a severe form of encephalitis caused by a flavivirus, a virus belonging to the Flaviviridae family, and transmitted by ticks (Ixodes pertulcatus and I. Ricinus). Synonym: Russian tick-borne encephalitis. (05 Mar 2000) |
| central excitatory state | The building up of excitatory influences produced by individual impulses finally causes firing of the next neuron. (05 Mar 2000) |
| central fibrous body | <anatomy, cardiology> The fibrous area where the leaflets of the aortic, mitral, and tricuspid valves meet in the heart. (05 Mar 2000) |
| central ganglioneuroma | <tumour> A rare lesion that contains neuronal (ganglion) cells in a sparse glial stoma. Synonym: central ganglioneuroma. Origin: Ganglion + G. Kytos, cell, + -oma, tumour (05 Mar 2000) |
| central gray substance | In general: the predominantly small-celled gray matter adjoining or surrounding the central canal of the spinal cord and the third and fourth ventricles of the brainstem, in particular: the thick sleeve of gray matter surrounding the cerebral sylvian aqueduct in the midbrain, rostrally continuous with the posterior nucleus of the hypothalamus; in sections stained for myelin it stands out from the adjoining tectum and tegmentum by the poverty of its myelinated fibres. Synonym: substantia grisea centralis. (05 Mar 2000) |
| central group of axillary lymph nodes | Nodes located around the midportion of the axillary vein; they receive afferent vessels from the lateral (brachial), pectoral, and subscapular groups of axillary nodes and send efferent vessels to the apical group of axillary node's. (05 Mar 2000) |
| central gyri | The precentral and postcentral gyri. Gyri cerebri Gyri of cerebrum, the gyri or convolutions of the cerebral cortex. Cingulate gyrus, a long, curved convolution of the medial surface of the cortical hemisphere, arched over the corpus callosum from which it is separated by the deep sulcus of corpus callosum; together with the parahippocampal gyrus, with which it is continuous behind the corpus callosum, it forms the fornicate gyrus. Synonym: gyrus cinguli, callosal convolution, callosal gyrus, cingulate convolution, falciform lobe, lobus falciformis. (05 Mar 2000) |
| central illumination | axial illumination |