| SPA | a fragment broken off from the edge or face of stone or ore and having at least one thin edge |
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| SPA | Italian physiologist who disproved the theory of spontaneous generation (1729-1799) |
| SPA | (physics) a nuclear reaction in which a bombarded nucleus breaks up into many particles |
| SPA | unwanted e-mail (usually of a commercial nature sent out in bulk) |
| SPA | send unwanted or junk e-mail |
| SPA | (trademark) a canned meat made largely from pork |
| SPA | someone who sends unwanted email (often in bulk) |
| SPA | the act of sitting or standing astride |
| SPA | a structure that allows people or vehicles to cross an obstacle such as a river or canal or railway etc. |
| SPA | the distance or interval between two points |
| SPA | a unit of length based on the width of the expanded human hand (usually taken as 9 inches) |
| SPA | two items of the same kind |