| receptors, lymphocyte homing | Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialised blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes. (12 Dec 1998) |
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| receptors, macrophage colony-stimulating factor | Glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response. (12 Dec 1998) |
| receptors, metabotropic glutamate | Cell surface proteins that bind glutamate and act through g-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action. (12 Dec 1998) |
| receptors, mineralocorticoid | Cytoplasmic proteins that specifically bind mineralocorticoids and mediate their cellular effects. The receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of DNA. Mineralocorticoids were named for their actions on extracellular electrolyte concentrations. The most important example is aldosterone. (12 Dec 1998) |
| receptors, mitogen | Glycoprotein molecules on the surface of b- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes. (12 Dec 1998) |
| receptors, muscarinic | One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for muscarine over nicotine. There are several subtypes (usually m1, m2, m3...) that are characterised by their cellular actions, pharmacology, and molecular biology. (12 Dec 1998) |
| receptors, nerve growth factor | Cell surface receptors that bind nerve growth factor (ngf) and trigger intracellular changes influencing the behaviour of cells. Nerve growth factor receptors mediate the effects of nerve growth factor on the survival and growth of neurons. (12 Dec 1998) |
| receptors, neurokinin-1 | A class of cell surface receptors for tachykinins with a preference for substance p. Neurokinin-1 (nk-1) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells. (12 Dec 1998) |
| receptors, neurokinin-2 | A class of cell surface receptors for tachykinins that prefers neurokinin a (nka, substance k, neurokinin alpha, neuromedin l), neuropeptide k (npk), or neuropeptide gamma over other tachykinins. Neurokinin-2 (nk-2) receptors have been cloned and are similar to other g-protein coupled receptors. (12 Dec 1998) |
| receptors, neurokinin-3 | A class of cell surface receptors for tachykinins that prefers neurokinin b (neurokinin beta, neuromedin k) over other tachykinins. Neurokinin-3 (nk-3) receptors have been cloned and are members of the g-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues. (12 Dec 1998) |
| receptors, neuropeptide | Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behaviour of cells. Many neuropeptides are also hormones outside of the nervous system. (12 Dec 1998) |
| receptors, neuropeptide y | Cell surface proteins that bind neuropeptide y with high affinity and trigger intracellular changes which influence the behaviour of cells. (12 Dec 1998) |
| receptors, neurotensin | Cell surface proteins that bind neurotensin with high affinity and trigger intracellular changes which influence the behaviour of cells. Neurotensin and neurotensin receptors are found in the central nervous system and in the periphery. (12 Dec 1998) |
| receptors, neurotransmitter | Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behaviour of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses. (12 Dec 1998) |
| receptors, nicotinic | One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for nicotine over muscarine. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, molecular biology, and biophysical properties of the channels. (12 Dec 1998) |