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primary amebic meningoencephalitis a rare and often fatal acute, febrile, purulent meningoencephalitis caused by usually free-living soil and water amebas of the genera Naegleria, Acanthamoeba, or Hartmannella. Infection caused by Naegleria is generally seen in young persons who swim or bathe in contaminated fresh water, the pathogens gaining access to the central nervous system by penetrating the nasal mucosa and cribriform plate and then following the olfactory bulbs and nerves to the brain and meninges. ...
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primary inoculation tuberculosis the cutaneous reaction at the site of inoculation of tubercle bacilli in individuals with no previous exposure to Mycobacterium tuberculosis, associated with prominent involvement of regional lymph nodes, and manifested by a chancriform (tuberculous chancre, the most common manifestation), impetiginous, or ecthymatous lesion. Called also primary inoculation complex and primary tuberculous complex.
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primary mental disorder [DSM-IV] any of the mental disorders that are neither due to a general medical condition nor substance-induced.
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primary sequestrum a sequestrum that is entirely detached.
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primary biliary cirrhosis a rare form of biliary cirrhosis of unknown etiology in which small intrahepatic bile ducts are destroyed while the major intra- and extrahepatic ducts remain patent; 90 per cent of patients are female; most are middle-aged; it is characterized by chronic cholestasis with pruritus, jaundice, hypercholesterolemia and xanthomas, osteomalacia, and, in the later stages, by portal hypertension and liver failure. Almost all patients have circulating antimitochondrial antibodies.
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