| genes, wilms' tumour | Tumour suppressor genes located in the 11p13 region on the short arm of human chromosome 11. The absence of these genes is associated with the formation of wilms' tumour. (12 Dec 1998) |
|---|---|
| VH and VL genes/domains | VH and VL genes define in part the sequences of the variable heavy and light regions of immunoglobulin molecules. VH and VL domains are the regions of amino acid sequence so defined. J genes and, in the case of the heavy chain, a D gene (D=diversity) also define these regions. Gene rearrangement also plays a role in determining the sequences in which the genes are joined as the DNA of the immunoglobulin producing cell matures. (18 Nov 1997) |
| mimic genes | Nonallelic (independent) gene's with closely similar effects, e.g., elliptocytosis. (05 Mar 2000) |
| homeotic genes | A group of genes that regulate the development of the body parts by defining the boundaries of the several regions. (05 Mar 2000) |
| housekeeping genes | Genes that are generally always expressed and thought to be involved in routine cellular metabolism. (05 Mar 2000) |
| SOS genes | A group of genes involved in DNA repair, often induced by damage severe enough to cause stoppage of DNA synthesis. (05 Mar 2000) |
| split genes | Genes where the genomic sequences are interrupted by intervening sequences (introns) that are spliced out of the mRNA prior to translation. (05 Mar 2000) |
| immune response genes | Gene's in the HLA-D region of the histocompatibility complex of human chromosome 6 which control the immune response to specific antigens. (05 Mar 2000) |
| transfer genes | Gene's carried by a conjugative plasmid, essential for fertility and establishment of the bacterial donor state. (05 Mar 2000) |
| acrocephalosyndactyly type 1 | <paediatrics> An inherited disease (autosomal dominant) or a spontaneously occurring disease characterised by a peaked head and unusual facial appearance, due to the premature closure of the cranial sutures. A skull X-ray can confirm the diagnosis and treatment is surgical. Inheritance: autosomal dominant. (27 Sep 1997) |
| Alzheimer type I astrocyte | Enlarged frequently multinucleated astrocytes, seen in progressive multifocal leukoencephalopathy. (05 Mar 2000) |
| Alzheimer type II astrocyte | Enlarged astrocytes with vesicular nuclei and one or more small basophilic nucleoli, seen in hepatocerebral disease and Wilson's disease. (05 Mar 2000) |
| American Type Culture Collection | <cell culture> A key resource for cultured cells, located in Rockville, USA. (12 Dec 1998) |
| Antoni type A neurilemoma | <tumour> Relatively solid or compact arrangement of neoplastic tissue that consists of Schwann cells arranged in twisting bundles and associated with delicate reticulin fibres; the nuclei of the Schwann cells are frequently grouped in parallel rows (so-called palisades), and the nuclei and fibres sometimes form exaggerated tactile corpuscles, called Verocay bodies. (05 Mar 2000) |
| Antoni type B neurilemoma | <tumour> Relatively soft or loose arrangement of neoplastic tissue that consists of Schwann cells in a haphazard or nondescript type of arrangement among reticulin fibres and tiny cystlike foci; fat-laden macrophages may be observed in some of the larger neoplasms. (05 Mar 2000) |