| end plate potential | <physiology> Depolarisation of the sarcolemma as a result of acetylcholine release from the motoneuron causing an influx of sodium ions. The endplate potential is the sum of quantal miniature endplate potentials. Development of the end plate potential is blocked by curare. (18 Nov 1997) |
|---|---|
| end point | <chemistry> It is the completion point during a titration reaction where there are equal amounts of titrant and whatever is being titrated. It is usually evident by the first perceptible alteration of the colour of an added indicator. <immunology> It is the most dilute an antibody or antiserum solution can be while still detectably reacting with the antigen. <statistics> A category of data used to compare the outcome in different arms of a clinical trial. Common endpoints are severe toxicity, disease progression or fall in such surrogate markers as CD4 count, but sometimes death is used as an endpoint. (08 Mar 2000) |
| end-point measurement | Analytical measurement at the end of a chemical reaction, as opposed to making the measurement while the reaction proceeds. (05 Mar 2000) |
| end-point nystagmus | A jerky, physiologic nystagmus occurring in a normal individual when attempts are made to fixate a point at the limits of the field of fixation. Synonym: deviational nystagmus. (05 Mar 2000) |
| end product | <biochemistry> The final product of after a series of reactions with enzymes in a biochemical metabolic pathway has taken place. (09 Oct 1997) |
| end product inhibition | <biochemistry, physiology> The process of the end product of a particular metabolic reaction inhibiting an allosteric enzyme involved in that reaction as the reaction starts again, thus breaking the reaction cycle. (09 Oct 1997) |
| end product repression | Catabolite repression in which the catabolite is an end product of a particular pathway. (05 Mar 2000) |
| end stage | The late, fully developed phase of a disease; e.g., in end-stage renal disease, a shrunken and scarred kidney that may result from a variety of chronic diseases that have become indistinguishable in their effect on the kidney. (05 Mar 2000) |
| end-stage renal disease | <nephrology> A patient with inadequate renal function to support life. Individuals with end-stage disease must rely in kidney dialysis or peritoneal dialysis to survive. End-stage renal disease may be caused by a number of problems including diabetes, sickle cell disease, hypertension and congenital renal disease (polycystic kidney disease). (27 Sep 1997) |
| end-systolic volume | The amount of blood in the ventricle at the end of the cardiac ejection period and immediately preceding the beginning of ventricular relaxation; a measurement of the adequacy of cardiac emptying, related to systolic function. (05 Mar 2000) |
| end-tidal | at the end of a normal expiration. (05 Mar 2000) |
| end-tidal sample | A sample of the last gas expired in a normal expiration, ideally consisting only of alveolar gas. (05 Mar 2000) |
| zero end-expiratory pressure | Airway pressure which, at the end of expiration, equals atmospheric pressure. (05 Mar 2000) |
| Krause's end bulbs | Nerve terminals in skin, mouth, conjunctiva, and other parts, consisting of a laminated capsule of connective tissue enclosing the terminal, branched, convoluted ending of an afferent nerve fibre; generally believed to be sensitive to cold. Synonym: corpuscula bulboidea, bulboid corpuscles. (05 Mar 2000) |
| flush end | <molecular biology> The ends of a blunt-end DNA molecule, where both strands in the double-stranded DNA molecule are even with each other rather than one strand being longer than the other. (09 Oct 1997) |