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dihydrolipoamide S- [EC 2.3.1.12] an enzyme of the transferase class that is a component of the multienzyme pyruvate dehydrogenase complex (q.v.). The enzyme catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA; the enzyme is itself the physiological lipoamide in the reaction. Called also dihydrolipoyltransacetylase.
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dihydrolipoamide acyltransferase an enzyme of the transferase class that is the lipoamide component of the multienzyme branched-chain α-keto acid dehydrogenase complex (q.v.). The enzyme catalyzes the transfer of the decarboxylated branched-chain acyl moiety to coenzyme A via its own lipoic acid group.
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dihydrolipoamide dehydrogenase [EC 1.8.1.4] an enzyme of the oxidoreductase class that catalyzes the regeneration of lipoamide from dihydrolipoamide, reducing NAD+. The enzyme contains FAD and is a component of several oxidative decarboxylation enzyme complexes: branched-chain α-keto acid dehydrogenase complex, α-ketoglutarate dehydrogenase complex, and pyruvate dehydrogenase complex; deficiency of the enzyme, an autosomal recessive trait, causes lipoamide dehydrogenase deficiency.
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dihydrolipoyl the acyl radical of dihydrolipoamide.
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dihydrolipoyltransacetylase dihydrolipoamide S-acetyltransferase.
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