| subacute necrotizing e. |
an encephalopathy of unclear clinical and pathological criteria, causing neuropathologic damage like that of the Wernicke-Korsakoff syndrome. It occurs in two forms: the infantile form, which may be the same as pyruvate carboxylase deficiency, is characterized by degeneration of gray matter with necrosis and capillary proliferation in the brain stem; hypotonia, seizures, and dementia; anorexia and vomiting; slow or arrested development; and ocular and respiratory disorders. Death usually occurs before age 3. The adult form usually first manifests as bilateral optic atrophy with central scotoma and colorblindness; then there is a quiescent period of up to 30 years; and then late symptoms appear such as ataxia, spastic paresis, clonic jerks, grand mal seizures, psychic lability, and mild dementia. Called also subacute necrotizing encephalopathy and Leigh disease.
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| subacute necrotizing l. |
Kikuchi's l.
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| subacute nodular migratory p. |
a condition considered by some to be the same as erythema nodosum migrans, characterized by the development on the anterior and lateral aspects of the lower extremities, particularly in women, of discrete nodules that spread centrifugally with erythematous borders and central clearing (giving the appearance of migration) and coalesce to form plaques that eventually involute, usually with residual pigmentation.
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| subacute r. |
a mild but protracted form of rheumatism.
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| subacute sclerosing l. |
subacute sclerosing panencephalitis.
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