| sickle c. |
an erythrocyte shaped like a sickle or crescent owing to the presence of hemoglobin S; seen in sickle cell anemia and other sickle cell diseases (see under disease). Called also drepanocyte and meniscocyte.
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| sickle cell a. |
an autosomal dominant type of hemolytic anemia, seen primarily in West Africa and in people of West African descent, and less often in the Mediterranean basin and a few other areas; it is caused by the presence of hemoglobin S with abnormal sickle-shaped erythrocytes (sickle cells). Homozygous individuals have 85 to 95 per cent sickle cells and have the full-blown syndrome with accelerated hemolysis, increased blood viscosity and vaso-occlusion, arthralgias, acute attacks of abdominal pain, ulcerations of the lower extremities, and periodic attacks of any of the conditions called sickle cell crises (see under crisis). The heterozygous condition is called sickle cell trait and is usually asymptomatic. See also sickle cell disease, under disease. Called also sicklemia.
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| sickle cell c. |
a broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vaso-occlusive crisis.
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| sickle cell d. |
any of the diseases associated with the presence of hemoglobin S and sickle cells, including sickle cell anemia, sickle cell–hemoglobin C disease, sickle cell–hemoglobin D disease, and sickle cell–thalassemia disease.
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| sickle cell n. |
chronic kidney pathology seen with sickle cell disease, including microangiopathy with capillary obstruction, dilated or obliterated vasa recta, enlarged glomeruli, interstitial fibrosis, and an increased glomerular filtration rate.
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