| MDT | mast [cell] degeneration test; mean dissolution time; median detection threshold; multidisciplinary ... |
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| NFD | neurofibrillary degeneration |
| OPCD | olivopontocerebellar degeneration |
| PCD | pacer-cardioverter-defibrillator; papillary collecting duct; paraneoplastic cerebellar degeneration;... |
| PRD | partial reaction of degeneration; physician relations department; postradiation dysplasia |
| Sorsby's macular degeneration | Macular degeneration that occurs during the fifth decade of life, with sudden development of a central scotoma in one eye followed rapidly by a similar lesion in the opposite eye; autosomal dominant inheritance. Synonym: Sorsby's macular degeneration. (05 Mar 2000) |
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| spinocerebellar degeneration | An autosomal recessive inherited disorder that leads to the progressive dysfunction of the cerebellum, spinal cord and peripheral nerves. Symptoms usually begin in childhood before puberty and consist of an unsteady gait (ataxia), slurred speech (dysarthria) and jerky eye movements (nystagmus). Other findings include kyphoscoliosis, hammer toe, heart disease and high arches. Congestive heart failure is a common complication. There is no known treatment and prognosis is poor. Inheritance: autosomal recessive. (27 Sep 1997) |
| spongy degeneration | <radiology> (Canavan disease) dysmyelinating disease, autosomal recessive, onset at 2 - 9 months, megalencephaly, (Alexander disease only other degenerative neurological disease in infants with big head!), blindness with or without deafness, hypotonia may lead to spasticity, Diagnosis: brain biopsy, centrum semiovale most severely affected (12 Dec 1998) |
| spongy degeneration of infancy | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
| nerve degeneration | Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. (12 Dec 1998) |
| neurofibrillary degeneration | Formation of coarse, argentophilic, intracytoplasmic fibres, often in complex tangles within intracranial nerve cells that are undergoing aging. See: Alzheimer's disease. (05 Mar 2000) |
| Nissl degeneration | Degeneration of the cell body occurring after transection of the axon; characterised by dispersion of the granular endoplasmic reticulum, swelling of the soma, and an eccentric position of the nucleus of the cell. (05 Mar 2000) |
| subacute combined degeneration of the spinal cord | A subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterised by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns. Synonym: combined sclerosis, combined system disease, funicular myelitis, Putnam-Dana syndrome, vitamin B12 neuropathy. (05 Mar 2000) |
| degeneration | An effect whereby the productivity of a microbial strain used in a commercial process diminishes after repeated transfer from one culture media to another, often caused by genetic mutation. (14 Nov 1997) |
| descending degeneration | Orthograde (wallerian) degeneration of an injured nerve fibre; i.e., distal to the lesion, degeneration caudal to the level of a spinal cord lesion. (05 Mar 2000) |
| disciform degeneration | Foveal or parafoveal subretinal neovascularization with retinal separation and haemorrhage leading finally to a circular mass of fibrous tissue with marked loss of visual acuity. Synonym: disciform macular degeneration. (05 Mar 2000) |
| disciform macular degeneration | Foveal or parafoveal subretinal neovascularization with retinal separation and haemorrhage leading finally to a circular mass of fibrous tissue with marked loss of visual acuity. Synonym: disciform macular degeneration. (05 Mar 2000) |
| infantile neuronal degeneration | <neurology, paediatrics> Degenerative disorder of infants with widespread neuronal loss in thalamus, cerebellum, pons, and spinal cord, resembling infantile muscular atrophy. (05 Mar 2000) |
| olivopontocerebellar degeneration | <neurology> An inherited disease especially. Of mid to late life that is characterised by ataxia, hypotonia, dysarthria, and degeneration of the cerebellar cortex, middle cerebellar peduncles, and inferior olives. (09 Oct 1997) |
| orthograde degeneration | <medicine> A form of degeneration occurring in nerve fibres as a result of their division; so called from Dr. Waller, who published an account of it in 1850. Source: Websters Dictionary (01 Mar 1998) |