| oxygen dependent killing | One of the most important bactericidal mechanisms of mammalian phagocytes involves the production of various toxic oxygen species (hydrogen peroxide, superoxide, singlet oxygen, hydroxyl radicals) through the metabolic burst. Although anaerobic killing is possible, the oxygen dependent mechanism is crucial for normal resistance to infection and a defect in this system is usually fatal within the first decade of life (chronic granulomatous disease). See: myeloperoxidase, chemiluminescence. (18 Nov 1997) |
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| T-dependent antigen | An antigen that requires T helper cells in addition to appropriate B-cells. Most antigens are T-dependent. (05 Mar 2000) |
| thiol-dependent peroxidase | <enzyme> From giardia intestinalis, which lacks glutathione; enzyme can also act with exogenous glutathione Registry number: EC 1.11.1.- Synonym: glutathione-linked thiol peroxidase (26 Jun 1999) |
| thymus-dependent zone | <anatomy> Mid cortical region of lymph node, area that is particularly depleted of T lymphocytes in thymectomised animals and is referred to as the thymus dependent area. (18 Nov 1997) |
| 3-phosphoinositide-dependent protein kinase | <enzyme> Enzyme from rabbit skeletal muscle phosphorylates protein kinase b at thr308; activated by phosphatidylinositol 3,4,5-trisphosphate or phosphatidylinositol 3,4-bisphosphate Registry number: EC 2.7.10.- Synonym: pdk1 enzyme, ptdins(3,4,5)p3-dependent protein kinase-1 (26 Jun 1999) |
| 8-hydroxy-5-deazaflavin-dependent DNA photolyase | <enzyme> From anacystis nidulans; purified in streptomyces coelicolor; distinguish from folate-dependent DNA photolyase Registry number: EC 4.1.99.- Synonym: 8-hdfd-DNA photolyase (26 Jun 1999) |
| L-glyceraldehyde 3-phosphate-NADPH-dependent oxidoreductase | <enzyme> Converts l-glyceraldehyde 3-phosphate to sn-glycerol 3-phosphate; does not act on d-glyceraldehyde 3-phosphate or dihydroxyacetone phosphate Registry number: EC 1.1.1.- Synonym: l-gap oxidoreductase (26 Jun 1999) |
| light dependent reaction | The reaction taking place in the chloroplast in which the absorption of a photon leads to the formation of ATP and NADPH. (18 Nov 1997) |