| hydroxymethylglutaryl-CoA reductase inhibitors | Compounds that inhibit hmg-CoA reductases. They have been shown to directly lower cholesterol synthesis. (12 Dec 1998) |
|---|---|
| hydroxymethylglutaryl CoA reductases | <enzyme> In the biosynthesis of cholesterol, these enzymes catalyze the reduction of one of the carboxyl groups of beta-hydroxy, beta-methylglutaryl CoA to yield mevalonic acid.4 requires NADP, EC 1.1.1.88 requires NAD. Chemical name: (S)-Mevalonate:NAD+ oxidoreductase (CoA-acylating) Registry number: EC 1.1.1.88 (12 Dec 1998) |
| hydroxymethylglutaryl-CoA synthase | <enzyme> An enzyme that catalyses the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. Chemical name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Registry number: EC 4.1.3.5 (12 Dec 1998) |
| hydroxymethylgutaryl-CoA hydrolase | <enzyme> May be important in regulating mammalian cholesterol synthesis Registry number: EC 3.1.2.5 Synonym: beta-hydroxy-beta-methylglutaryl coenzyme a hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme a deacylase (26 Jun 1999) |
| sphingosine CoA-independent transacetylase | <enzyme> Transfers the acetate group from platelet-activating factor (paf) to sphingosine forming n-acetylsphingosine (c2-ceramide) Registry number: EC 2.3.1.- Synonym: platelet-activating factor-sphingosine transacetylase, paf-sphingosine transacetylase, paf-sph transacetylase (26 Jun 1999) |
| stearoyl-CoA desaturase | <enzyme> An enzyme that catalyses the formation of oleoyl-CoA, a, and water from stearoyl-CoA, ah2, and oxygen where ah2 is an unspecified hydrogen donor. Chemical name: Stearoyl-CoA,hydrogen-donor:oxygen oxidoreductase Registry number: EC 1.14.99.5 (12 Dec 1998) |
| stearyl-CoA | Stearyl-coenzyme A The coenzyme A thioester of stearic acid; precursor to oleic acid and, in the brain, the C22 and C24 fatty acids present in sphingomyelins; in the brain, use of stearyl-CoA increases during myelination. (05 Mar 2000) |
| stearyl-CoA desaturase | A protein complex that is key in the synthesis of unsaturated fatty acids; it introduces a double bond at d9; high dietary levels of unsaturated fatty acids decrease this enzyme's activity in the liver; a number of agents will induce this enzyme (e.g., insulin, hydrocortisone, and triiodothyronine). (05 Mar 2000) |
| succinate-CoA ligases | <enzyme> Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (ec 6.2.1.5) or GTP to GDP (ec 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and itp instead of GTP.ec 6.2.1.-. Chemical name: Succinate:CoA ligase (GDP- or ADP-forming) Registry number: EC 6.2.1.- (12 Dec 1998) |
| succinyl CoA | An intermediate product in the tricarboxylic acid cycle. (18 Nov 1997) |
| succinyl-CoA | The condensation product of succinic acid and CoA; one of the intermediates of the tricarboxylic acid cycle and a precursor in the synthesis of haem. Synonym: active succinate, succinyl-CoA. (05 Mar 2000) |
| succinyl-CoA hydrolase | <enzyme> Enzyme from trichosporon cutaneum; acts on succinyl-CoA and methylsuccinyl CoA to give free acids Registry number: EC 3.1.2.3 Synonym: methylsuccinyl-CoA hydrolase, succinyl-coenzyme a hydrolase (26 Jun 1999) |
| succinyl-CoA ligase | A ligase reversibly reacting succinate and CoA with ATP to produce ADP, inorganic phosphate, and succinyl-CoA, a similar synthetase, but one able to use itaconate as well as succinate and GTP (or ITP) in place of ATP; a part of the tricarboxylic acid cycle. Synonym: succinic thiokinase, succinyl-CoA ligase. (05 Mar 2000) |
| succinyl-CoA synthetase | A ligase reversibly reacting succinate and CoA with ATP to produce ADP, inorganic phosphate, and succinyl-CoA, a similar synthetase, but one able to use itaconate as well as succinate and GTP (or ITP) in place of ATP; a part of the tricarboxylic acid cycle. Synonym: succinic thiokinase, succinyl-CoA ligase. (05 Mar 2000) |
| succinyl-CoA-tetrahydrodipicolinate N-succinyltransferase | <enzyme> Catalyses formation of CoA and n-succinyl-2-amino-6-keto-l-pimelate from succinyl-CoA and tetrahydrodipicolinate Registry number: EC 2.3.1.- Synonym: tetrahydrodipicolinate succinylase, tetrahydrodipicolinate n-succinyltransferase, succinyl-coenzyme a-tetrahydrodipicolinate n-succinyltransferase (26 Jun 1999) |