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lysine dehydrogenase an enzyme of the oxidoreductase class that catalyzes the oxidative deamination of lysine, removing the α-amino acid as the first step in a minor pathway of lysine degradation (see also α-aminoadipic semialdehyde synthase). Deficiency of the enzyme, an autosomal recessive trait, causes congenital lysine intolerance.
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lysine i., congenital an autosomal recessive disorder due to a defect in the degradation of lysine, characterized by high levels of ammonia, lysine, and arginine in the blood, with vomiting, rigidity, and coma. Cf. hyperlysinemia.
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lysine ketoglutarate reductase saccharopine dehydrogenase (NADP+, L-lysine-forming).
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lysine v. the antidiuretic hormone of the pig family, differing from arginine vasopressin in having lysine instead of arginine at position 8; used pharmaceutically as the synthetic preparation lypressin (q.v.).
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lysine-iron agar an agar medium containing peptone, yeast extract, glucose, L-lysine, ferric ammonium citrate, sodium thiosulfate, and bromcresol purple, used to determine lysine decarboxylase and lysine deaminase in the Enterobacteriaceae, especially for the genera Proteus and Providencia.
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