| myeloid sarcoma | <tumour> A malignant tumour of immature myeloid cells, frequently subperiosteal, associated with or preceding granulocytic leukaemia. See: chloroma. Synonym: myeloid sarcoma. (05 Mar 2000) |
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| porcine sarcoma virus | A retrovirus causing sarcoma in swine. (05 Mar 2000) |
| Harvey sarcoma virus | <oncogene> One of a family of oncogenes, first identified as transforming genes of Harvey and Kirsten murine sarcoma viruses. (Name from rat sarcoma because Harvey virus, though a mouse virus, obtained its transforming gene during passage in a rat). Transforming protein coded is p21ras, a GTP-binding protein with GTPase activity, that resembles regulatory G-proteins. (18 Nov 1997) |
| sarcoma | <oncology, tumour> A form of cancer that arises in the supportive tissues such as bone, cartilage, fat or muscle. Kaposi sarcoma: a sarcoma of spindle cells mixed with angiomatous tissue. Usually classed as an angioblastic tumour. A fairly frequent concomitant to HIV. Infection or long term immunosuppresion. (14 May 1997) |
| sarcoma, alveolar soft part | A variety of sarcoma having a reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue. It is a rare tumour, usually occurring between 15 and 35 years of age. It appears in the muscles of the extremities in adults and most commonly in the head and neck region of children. Though slow-growing, it commonly metastasizes to the lungs, brain, bones, and lymph nodes. (12 Dec 1998) |
| sarcoma, avian | Connective tissue tumours, affecting primarily fowl, that are usually caused by avian sarcoma viruses. (12 Dec 1998) |
| sarcoma botryoides | <radiology> Type of embryonal rhabdomyosarcoma, mass resembles bunch of grapes, originates submucosally, grows into lumen (12 Dec 1998) |
| sarcoma cell | Cells of a malignant tumour derived from connective tissue. Often given a prefix denoting tissue of origin, for example osteosarcoma (from bone). (18 Nov 1997) |
| sarcoma, clear cell | A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumours of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (12 Dec 1998) |
| sarcoma, endometrial stromal | A highly malignant neoplasm of the endometrium, arising from the endometrial stroma. It represents one type of stromal tumour, the other being endolymphatic stromal myosis. They are differentiated on the basis of the number of mitoses per 10 high power fields: endometrial stromal sarcoma has 10 or more mitoses, endolymphatic stromal myosis fewer. Stroma sarcoma is seen most often between the ages of 45 and 50. (devita jr et al., cancer: principles & practice of oncology, 3d ed, p1146) (12 Dec 1998) |
| sarcoma, ewing's | A malignant tumour of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumour occurs usually before the age of 20, about twice as frequently in males as in females. (12 Dec 1998) |
| sarcoma growth factor | <growth factor> Polypeptide released by sarcoma cells that promotes the growth of cells by binding to a cell surface receptor, the sarcoma cell is therefore self sufficient and independent of normal growth control. See: growth factors. The name is no longer commonly used. (18 Nov 1997) |
| sarcoma, kaposi | A multicentric, malignant neoplastic vascular proliferation characterised by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumours have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in jewish and italian males in europe and the united states. An aggressive variant in young children is endemic in some areas of africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in aids patients. Hhv-8 is the suspected cause. (12 Dec 1998) |
| sarcoma, small cell | A sarcoma characterised by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (12 Dec 1998) |
| sarcoma, synovial | A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumour can occur in the abdominal wall and other trunk muscles. There are two recognised types: the monophasic (characterised by sheaths of monotonous spindle cells) and the biphasic (characterised by slit-like spaces or clefts within the tumour, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (12 Dec 1998) |