| glucose-6-phosphate dehydrogenase deficiency | A deficiency of glucose-6-phosphate dehydrogenase, an enzyme important for maintaining cellular concentrations of reduced nucleotides. Deficiency of this enzyme is the commonest disease-causing enzyme defect in humans affecting an estimated 400 million people. The gene for this enzyme is on the X chromosome and there are various polymorphic forms. Males with the enzyme deficiency develop haemolytic anaemia when red blood cells are exposed to oxidant drugs such as the antimalarial primaquine, the sulfonamide antibiotics or sulfones, naphthalene moth balls, or fava beans. It can also cause anaemia of the newborn, and chronic nonspherocytic haemolytic anaemia. Inheritance: X-linked. (12 Sep 2002) |
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| glucose-6-phosphate translocase | <enzyme> A component of EC 3.1.3.9 which transports glucose phosphate into endoplasmic reticulum Registry number: EC 2.7.- Synonym: t1 transport protein (26 Jun 1999) |
| glucose clamp technique | <technique> Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration. (12 Dec 1998) |
| glucose dehydrogenase | <enzyme> Converts beta-d-glucose to d-glucono-d-lactone, transferring hydrogen to NAD+ or NADP+. Compare: glucose oxidase. (05 Mar 2000) |
| glucose dehydrogenases | <enzyme> D-glucose:1-oxidoreductases. Catalyses the oxidation of d-glucose to d-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Registry number: EC 1.1.1. (12 Dec 1998) |
| glucose effect | <biochemistry> The ability of the sugar glucose to block sugar metabolism by keeping the genes which make the enzymes involved in the early steps of sugar metabolism from making those enzymes. (09 Oct 1997) |
| glucose-fructose oxidoreductase | <enzyme> Isolated from zymomonas mobilis; catalyses the formation of sorbitol and glucono-delta-lactone from glucose and fructose; enzyme contains tightly bound nadp+ Registry number: EC 1.1.99.- (26 Jun 1999) |
| glucose intolerance | A pathological state in which the fasting plasma glucose level is less than 140 mg per deciliter and the 30-, 60-, or 90-minute plasma glucose concentration following a glucose tolerance test exceeds 200 mg per deciliter. This condition is seen frequently in diabetes mellitus but also occurs with other diseases. (12 Dec 1998) |
| glucose oxidase | <enzyme> An enzyme which converts glucose into gluconic acid and hydrogen peroxide (H2O2). It is used to help diagnose diabetes by determining if glucose is present in the patients urine, if the glucose is present, the hydrogen peroxide produced in the reaction can be detected by reacting it with an indicator to change the colour of the urine. (09 Oct 1997) |
| glucose oxidase method | <chemical pathology> A highly specific method for measurement of glucose in serum or plasma by reaction with glucose oxidase, in which gluconic acid and hydrogen peroxide are formed. (05 Mar 2000) |
| glucose oxidase paper strip test | <chemical pathology> A qualitative test for glucose in the urine, in which glucose is oxidised to gluconic acid by glucose oxidase; a specific test, unless ascorbic acid is present. (05 Mar 2000) |
| glucose oxyhydrase | <enzyme> An enzyme which converts glucose into gluconic acid and hydrogen peroxide (H2O2). It is used to help diagnose diabetes by determining if glucose is present in the patients urine, if the glucose is present, the hydrogen peroxide produced in the reaction can be detected by reacting it with an indicator to change the colour of the urine. (09 Oct 1997) |
| glucose phosphomutase | <enzyme> An enzyme that catalyses the conversion of alpha d-glucose 1-phosphate to alpha d-glucose-6-phosphate. Chemical name: alpha-D-Glucose 1,6-phosphomutase Registry number: EC 5.4.2.2 (12 Dec 1998) |
| glucose related protein | <protein> One of the stress related proteins: identical to endoplasmin. (18 Nov 1997) |
| glucose solution, hypertonic | Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent. (12 Dec 1998) |