| aldose reductase | A polyol dehydrogenase (NADP+);an oxidoreductase that reversibly converts aldoses to alditols (e.g., glucose to sorbitol) with NADPH as hydrogen donor. An important step in the metabolism of sorbitol and in the formation of diabetic cataracts. See: d-sorbitol-6-phosphate dehydrogenase. (05 Mar 2000) |
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| aldose reductase inhibitor | <pharmacology> A class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose (sugar) into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy and neuropathy. Drugs that prevent or slow (inhibit) the action of aldose reductase are being studied as a way to prevent or delay these complications of diabetes. (09 Oct 1997) |
| alkyl hydroperoxide reductase | <enzyme> Reduces an alkyl hydroperoxide to the corresponding alcohol in the presence of NADPH; ahpc gene product from salmonella typhimurium Registry number: EC 1.- Synonym: ahpc gene product, alkylhydroperoxide reductase, ahpf gene product (26 Jun 1999) |
| alpha,beta-ketoalkene reductase | <enzyme> Nadh is much less effective than NADPH; catalyses the reduction of the carbon-carbon double bond of five membered ring cpds which have two conjugated carbonyl groups on both sides of a double bond Registry number: EC 1.3.1.- Synonym: n-ethylmaleimide reducing enzyme, NADPH-linked alpha,beta-ketoalkene double bond reductase, n-ethylmaleimide reductase (26 Jun 1999) |
| alpha-santonin-1,2-reductase | <enzyme> From pseudomonas cichorii s.; catalyses the reduction of the 1,2-double bond of santonin; NADH or NADPH dependent Registry number: EC 1.3.1.- Synonym: santonin 1,2-reductase (26 Jun 1999) |
| amine tetrazolium reductase | <enzyme> Tetrazolium salts as hydrogen acceptors Registry number: EC 1.4.- Synonym: tryptamine dehydrogenase, monoamine tetrazolium reductase, monoamine dehydrogenase (26 Jun 1999) |
| aponitrite reductase | <enzyme> Translocated to the periplasm of paracoccus denitrificans in the absence of haem incorporation Registry number: EC 1.6.6.- Synonym: apocytochrome cd1, apocytochrome cd(1) (26 Jun 1999) |
| aquacobalamin reductase | <enzyme> Found in bacteria and vertebrates; catalyses the reduction of 2 aquacob(iii)alamin to 2 cob(ii)alamin in the presence of NADH; see also aquacobalamin reductase (NADPH) (EC 1.6.99.11) Registry number: EC 1.6.99.8 Synonym: NADH-linked aquacobalamine reductase, cob(iii)alamin reductase, aquacobalamine reductase (NADH) (26 Jun 1999) |
| benzopyrene 4,5-oxide reductase | <enzyme> Nadph and cytochrome p-450-dependent reduces epoxide to glycol Registry number: EC 1.- Synonym: benzo(a)pyrene 4,5-epoxide reductase, bap 4,5-or, benz(a)pyrene 4,5-oxide reductase (26 Jun 1999) |
| beta-ketoacyl-ACP reductase | A part of the fatty acid synthase complex; an enzyme reversibly reacting 3-oxoacyl-ACP with NADPH to form d-3-hydroxyacyl-ACP and NADP+. Synonym: beta-ketoacyl-ACP reductase. (05 Mar 2000) |
| biotin sulfoxide reductase | <enzyme> Biotin sulfoxide + protein(sh)2 yields biotin + protein-s2 + h20 Registry number: EC 1.- (26 Jun 1999) |
| bis-gamma-glutamylcystine reductase | <enzyme> From halobacterium halobium; specific for NADPH Registry number: EC 1.6.4.- Synonym: bis-ggc reductase (26 Jun 1999) |
| canavanine reductase | <enzyme> Forms guanidine Registry number: EC 1.4.- (26 Jun 1999) |
| carbon dioxide reductase | <enzyme> Co is oxidised to co2; carbon dioxide may be reduced to formate; co dehydrogenase contains a (ni/fe-s) enzyme and a (corrinoid/fe-s) enzyme component; has co-beta-methylcobamide/tetrahydropteridine methyltransferase and acetyl-CoA synthase activities Registry number: EC 1.2.99.2 Synonym: co2 reductase, ferredoxin-co2 oxidoreductase, carbon monoxide dehydrogenase, co dehydrogenase, formate dehydrogenase, ferredoxin-dependent, acetyl-CoA decarbonylase synthase complex, acds complex, molybdenum co dehydrogenase (26 Jun 1999) |
| carbon monoxide dehydrogenase disulfide reductase | <enzyme> Catalyses a reversible exchange of coash with acetyl-CoA in combination with carbon monoxide dehydrogenase (EC 1.2.99.2) Registry number: EC 1.8.- Synonym: co dehydrogenase disulfide reductase, co-dd-reductase (26 Jun 1999) |