| antigens, CD18 | <immunology> Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (receptors, leukocyte-adhesion). A defect in the gene encoding CD18 causes leukocyte-adhesion deficiency syndrome. (12 Dec 1998) |
|---|---|
| antigens, CD19 | <immunology> Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation. (12 Dec 1998) |
| antigens, CD2 | <immunology> Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex. (12 Dec 1998) |
| antigens, CD20 | <immunology> Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane calcium conductance and thought to play a role in B-cell activation and proliferation. (12 Dec 1998) |
| antigens, CD26 | <enzyme, immunology> Cell-surface glycoproteins and serine protease, also known as dipeptidyl-peptidase IV, that play a role in t-lymphocyte activation. Cd26 binds to adenosine deaminase on the T-cell surface. Registry number: EC 3.4.14.5 (12 Dec 1998) |
| antigens, CD27 | <immunology> Dimeric membrane glycoproteins found on most T-lymphocytes. Activation of T-cells by the antigen receptor increases CD27 surface expression. (12 Dec 1998) |
| antigens, CD28 | <immunology> T-cell differentiation antigens that serve as the receptors for the b7 antigen (antigens, CD80) which modulates T-cell lymphokine production. (12 Dec 1998) |
| antigens, CD29 | <immunology> Integrin beta-1 chains which are expresssed as heterodimers noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). Cd29 is expressed on resting and activated leukocytes and is a marker for total very late activation antigens on cells. (barclay et al., the leukocyte antigen factsbook, 1993, p164) (12 Dec 1998) |
| antigens, CD3 | <immunology> A complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (receptors, antigen, T-cell). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (receptors, antigen, T-cell, gamma-delta). (12 Dec 1998) |
| antigens, CD30 | <immunology> Differentiation antigens normally present in a small number of cells in the lymph nodes and tonsils in vivo, but also capable of being induced in a wide range of cells in vitro. They are clinically useful as tumour markers for ki-1 lymphoma (lymphoma, large-cell, ki-1) and some cases of lymphomatoid papulosis, mycosis fungoides, and hodgkin's disease. (12 Dec 1998) |
| antigens, CD31 | <immunology> Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. Cd31 is highly expressed on endothelial cells and concentrated at the junctions between them. (12 Dec 1998) |
| antigens, CD34 | <immunology> Glycoproteins found on immature haematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow. (12 Dec 1998) |
| antigens, CD36 | <immunology> Leukocyte differentiation antigens and major platelet membrane glycoproteins present on monocytes, endothelial cells, platelets, mammary epithelial cells, and a variety of cultured cell lines. They play major roles in adhesion phenomena, signal transduction, and haematopathology. Cd36 is also the receptor for thrombospondin and malaria-infected erythrocytes. (12 Dec 1998) |
| antigens, CD4 | <immunology> 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV. The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other. (12 Dec 1998) |
| antigens, CD40 | <immunology> Differentiation antigens found on all mature B-lymphocytes and some epithelial cells, carcinomas, and lymphoid dendritic cells. This is a member of the tumour necrosis factor superfamily. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centres. (12 Dec 1998) |