| MN blood group antigens | <haematology, immunology> A pair of blood group antigens governed by genes that segregate independently of the ABO locus. The alleles are codominant and there are three types MM, NN and MN. Glycophorin has M or N activity and this is associated with oligosaccharides attached to the amino terminal portion of the molecule. M type glycophorin differs from N type in amino acid residues 1 and 5, although the antigenic determinants are associated with the carbohydrate side chains. (18 Nov 1997) |
|---|---|
| hepatitis antigens | Antigens from any of the hepatitis viruses including surface, core, and other associated antigens. (12 Dec 1998) |
| hepatitis b e antigens | A closely related group of antigens found in the plasma only during the infective phase of hepatitis b or in virulent chronic hepatitis b, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins g. (12 Dec 1998) |
| hepatitis b surface antigens | Those hepatitis b antigens found on the surface of the dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen. (12 Dec 1998) |
| hepatitis c antigens | Antigens of the virions of hepatitis c-like viruses, their surface, core, or other associated antigens. (12 Dec 1998) |
| histocompatibility antigens | A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection. (12 Dec 1998) |
| HIV antigens | Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (lav) antigens. (12 Dec 1998) |
| HLA-a antigens | <immunology> Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. at least 20 antigens have been identified which are encoded by the a locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts. (12 Dec 1998) |
| HLA antigens | <immunology> A complex family of genetically inherited proteins which are found on the surface of cells throughout the body. They determine the match between patient and potential donor in bone marrow transplantation. These factors are inherited from the mother and father and so the chance of having the same HLA antigens between siblings is 1 in 4. See: human lymphocyte antigens. (20 Jun 2000) |
| HLA-b antigens | <immunology> Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus b of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-b27, -b7, -b8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic t lymphocytes. (12 Dec 1998) |
| HLA-c antigens | <immunology> Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the c locus on chromosome 6. They have significantly lower immunogenicity than the HLA-a and -b determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma). (12 Dec 1998) |
| HLA-d antigens | <immunology> Human immune-response or class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-d locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -dr, -dq and -dp designations, of which HLA-dr is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune aetiology. (12 Dec 1998) |
| HLA-dp antigens | <immunology> A group of the d-related HLA antigens (human) found to differ from the dr antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (12 Dec 1998) |
| HLA-dq antigens | <immunology> A group of the d-related HLA antigens found to differ from the dr antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (12 Dec 1998) |
| HLA-dr antigens | <immunology> A group of d-related human leukocyte antigens that are polymorphic glycoproteins found on lymphoid cells. They consist of alpha and beta chains and their inheritance differs from that of the dq and dp antigens; their presence seems to be associated with certain skin diseases like pemphigus vulgaris, dermatitis herpetiformis, and type I diabetes. (12 Dec 1998) |