| anaemia of chronic disease | <disease> A form of anaemia which develops as the result of a long-term infection or illness. Chronic diseases can interfere with red blood cell production in addition to shortening red blood cell life span in the body. Symptoms are largely due to the underlying disease. Haemoglobin and haematocrit are generally low. Iron studies may be low to normal. Red blood cell indices may usually normal. (27 Sep 1997) |
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| candidiasis, chronic mucocutaneous | A clinical syndrome characterised by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy. (12 Dec 1998) |
| granulomatous disease, chronic | A recessive x-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. (12 Dec 1998) |
| persistent chronic hepatitis | A benign chronic hepatitis that may follow acute viral hepatitis A or B, or complicate bowel diseases; after six months, liver biopsy changes are mild, unlike active chronic hepatitis; rarely, if ever, progresses to cirrhosis, portal hypertension, or liver failure. (05 Mar 2000) |
| chronic | Persisting over a long period of time. Origin: L. Chronicus, Gr. Chronos = time (18 Nov 1997) |
| chronic abscess | A long-standing collection of pus surrounded by fibrous tissue. (05 Mar 2000) |
| chronic absorptive arthritis | Arthritis accompanied by pronounced resorption of bone with shortening and deformity, especially of the hands; when the deformity is extreme, the condition has also been termed arthritis mutilans. (05 Mar 2000) |
| chronic acholuric jaundice | <haematology> A hereditary disorder that leads to a chronic haemolytic anaemia due to an abnormality in the red blood cell membrane. This disorder is caused by a defective gene. Red cells are resistant to stress and rupture easily. Infants may appear jaundiced and pale. Fatigue, weakness and shortness of breath are other symptoms that may be seen in older patients. The spleen may also be enlarged. Treatment includes splenectomy (removal of the spleen). After this is accomplished the life-span of the red blood cells returns to normal. (27 Sep 1997) |
| chronic active hepatitis | <pathology> This is a form of continuing liver inflammation that results in liver cell death. Causes include viral infection (hepatitis D, hepatitis B, hepatitis C), autoimmune disease, drug ingestion or metabolic causes. Chronic active hepatitis will lead to hepatic failure and death in a small percentage of these patients. (27 Sep 1997) |
| chronic active inflammation | The coexistence of chronic inflammation and superimposed acute inflammation. (05 Mar 2000) |
| chronic active liver disease | Any of several types of hepatitis persisting for more than six months, often progressing to cirrhosis. Synonym: chronic active liver disease. (05 Mar 2000) |
| chronic adrenocortical insufficiency | Adrenocortical insufficiency usually as the result of idiopathic atrophy or destruction of both adrenal glands by tuberculosis, an autoimmune process, or other diseases; characterised by fatigue, decreased blood pressure, weight loss, increased melanin pigmentation of the skin and mucous membranes, anorexia, and nausea or vomiting; without appropriate replacement therapy, it can progress to acute adrenocortical insufficiency. Synonym: Addison's disease, addisonian syndrome, hyposupradrenalism, morbus Addisonii. (05 Mar 2000) |
| chronic African sleeping sickness | A chronic disease of humans caused by Trypanosoma brucei gambiense in northern and sub-Saharan Africa from Senegal east to Sudan and Uganda; characterised by splenomegaly, drowsiness, an uncontrollable urge to sleep, and the development of psychotic changes; basal ganglia and cerebellar involvement commonly lead to chorea and athetosis; the terminal phase of the disease is characterised by wasting, anorexia, and emaciation that gradually leads to coma and death, usually from intercurrent infection. Synonym: chronic African sleeping sickness, chronic trypanosomiasis, West African sleeping sickness, West African trypanosomiasis. (05 Mar 2000) |
| chronic alcoholism | A pathologic condition, affecting chiefly the nervous and gastroenteric systems, associated with impairment in social and occupational functioning, caused by the habitual use of alcoholic beverages in toxic amounts. See: gamma alcoholism. (05 Mar 2000) |
| chronic allograft rejection | Immunologically mediated damage to the allograft, typically a kidney allograft, manifested by diffuse interstitial fibrosis glomerular changes, typically membranous and sclerotic in nature, as well as intimal fibrosis of the blood vessels with tubular atrophy and loss of tubular structures. (05 Mar 2000) |