| central core disease | A congenital myopathy characterised by hypotonia, delay of motor development in infancy, and nonprogressive or slowly progressive muscle weakness; on biopsy the central core of muscle fibres stains abnormally, myofibrils are abnormally compact, and there is virtual absence of mitochondria and sarcoplasmic reticulum; histochemically, the cores are devoid of oxidative enzyme, phosphorylase, and ATPase activity; autosomal dominant inheritance, often subclinical. (05 Mar 2000) |
|---|---|
| central core disease of muscle | <neurology> One of the conditions that produces floppy baby syndrome. It causes hypotonia (floppiness) in the newborn baby, slowly progressive muscle weakness, and muscle cramps after exercise. Muscle biopsy shows a key diagnostic finding (absent mitochondria in the centre of many type I muscle fibres). The disease is inherited as a dominant trait. The CCD gene is on chromosome 19 (and involves ryanodine receptor-1). Inheritance: autosomal dominant. (12 Dec 1998) |
| central deafness | Deafness due to disorder of the auditory system of the brainstem or cerebral cortex. (05 Mar 2000) |
| central dogma | <molecular biology> The main principle of molecular biology, coined by Francis Crick, which states that genetic information flows from DNA to RNA to protein. (09 Oct 1997) |
| Central European tick-borne encephalitis virus | One of the virus's of the tick-borne encephalitis complex of group B arboviruses (genus Flavivirus); the causative agent of tick-borne encephalitis (Central European subtype). (05 Mar 2000) |
| Central European tick-borne fever | 1. (Central European subtype) tick-borne meningoencephalitis caused by a flavivirus closely related to the virus causing the Far Eastern type; it is transmitted by Ixodes ricinus, also by infected raw milk, especially that of goats. Synonym: biundulant meningoencephalitis, Central European tick-borne fever, diphasic milk fever, Russian spring-summer encephalitis (Western subtype). 2. (Eastern subtype) tick-borne encephalitis, a severe form of encephalitis caused by a flavivirus, a virus belonging to the Flaviviridae family, and transmitted by ticks (Ixodes pertulcatus and I. Ricinus). Synonym: Russian tick-borne encephalitis. (05 Mar 2000) |
| central excitatory state | The building up of excitatory influences produced by individual impulses finally causes firing of the next neuron. (05 Mar 2000) |
| central fibrous body | <anatomy, cardiology> The fibrous area where the leaflets of the aortic, mitral, and tricuspid valves meet in the heart. (05 Mar 2000) |
| central ganglioneuroma | <tumour> A rare lesion that contains neuronal (ganglion) cells in a sparse glial stoma. Synonym: central ganglioneuroma. Origin: Ganglion + G. Kytos, cell, + -oma, tumour (05 Mar 2000) |
| central gray substance | In general: the predominantly small-celled gray matter adjoining or surrounding the central canal of the spinal cord and the third and fourth ventricles of the brainstem, in particular: the thick sleeve of gray matter surrounding the cerebral sylvian aqueduct in the midbrain, rostrally continuous with the posterior nucleus of the hypothalamus; in sections stained for myelin it stands out from the adjoining tectum and tegmentum by the poverty of its myelinated fibres. Synonym: substantia grisea centralis. (05 Mar 2000) |
| central group of axillary lymph nodes | Nodes located around the midportion of the axillary vein; they receive afferent vessels from the lateral (brachial), pectoral, and subscapular groups of axillary nodes and send efferent vessels to the apical group of axillary node's. (05 Mar 2000) |
| central gyri | The precentral and postcentral gyri. Gyri cerebri Gyri of cerebrum, the gyri or convolutions of the cerebral cortex. Cingulate gyrus, a long, curved convolution of the medial surface of the cortical hemisphere, arched over the corpus callosum from which it is separated by the deep sulcus of corpus callosum; together with the parahippocampal gyrus, with which it is continuous behind the corpus callosum, it forms the fornicate gyrus. Synonym: gyrus cinguli, callosal convolution, callosal gyrus, cingulate convolution, falciform lobe, lobus falciformis. (05 Mar 2000) |
| central illumination | axial illumination |
| central implantation | <obstetrics> Implantation in which the blastocyst remains in the uterine cavity, as in carnivores, rhesus monkeys, and rabbits. Synonym: circumferential implantation, superficial implantation. (05 Mar 2000) |
| central incisor | <dentistry> The first tooth in the maxilla and mandible on either side of the midsagittal plane of the head. (05 Mar 2000) |