| phenothiazine | <pharmacology> A group of tranquilising medications with antipsychotic action, thought to act by blocking dopaminergic transmission in the brain. They are used to treat mental, nervous and emotional disorders. Examples include: chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine, trifluoperazine, thiopropazate and triflupromazine. Trifluoperazine binds to and inhibits calmodulin and has been used experimentally to block calcium or calmodulin controlled reactions. (29 Sep 1997) |
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| phenothiazine sulfoxidase | <enzyme> Converts ethionamide, chlorpromazine and thioridazine to their corresponding sulfoxides; requires NADPH and oxygen; does not contain p-450 Registry number: EC 1.8.- Synonym: ethionamide sulfoxidase (26 Jun 1999) |
| phenotype | <biology, genetics> The total characteristics displayed by an organism under a particular set of environmental factors, regardless of the actual genotype of the organism. Results from interaction between the genotype and the environment. (09 Jan 1998) |
| phenotypic | Relating to phenotype. (05 Mar 2000) |
| phenotypic threshold | A quantitative genetic trait with a continuous distribution termed its liability may generate two kinds of phenotype, according to whether the liability lies above or below some critical threshold at about which a radical change in behaviour occurs. For instance, blood uric acid level is a liability with an approximately gaussian distribution. At a critical point of chemical saturation (the threshold crystallization occurs and the resulting gout or nongout is a threshold trait. (05 Mar 2000) |
| phenotypic value | In quantitative genetics, the metrical quantity of some trait associated with a particular phenotype. (05 Mar 2000) |
| phenoxazine | Phenothiazine in which S is replaced by O; as the 3-oxo derivative (phenoxazone), phenoxazine is the chromophore of actinomycins. (05 Mar 2000) |
| phenoxazone | See: phenoxazine. (05 Mar 2000) |
| phenoxybenzamine | <chemical> N-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl) benzenemethanamine. An alpha-adrenergic anatagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. Pharmacological action: adrenergic alpha-antagonists, antihypertensive agents, sympatholytics, vasodilator agents. Chemical name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)- (12 Dec 1998) |
| phenoxybenzamine hydrochloride | (2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl benzylamine hydrochloride;a potent adrenergic (alpha-receptor) blocking agent of the beta-haloalkylamines; selectively blocks the excitatory response of smooth muscle and exocrine glands to epinephrine; used in the treatment of peripheral vascular diseases and in pheochromocytoma. (05 Mar 2000) |
| phenoxybenzoate dioxygenase | <enzyme> Catalyses conversion of 3- or 4-phenoxybenzoate to phenol and protocatechuate via a putative hemiacetal intermediate. Registry number: EC 1.14.14.- Synonym: 4-carboxydiphenyl ether dioxygenase, pob dioxygenase, pobb gene product (26 Jun 1999) |
| phenoxymethylpenicillin | <chemical> (2s-(2 alpha,5 alpha,6 beta)-3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylic acid. A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. Pharmacological action: penicillins. Chemical name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))- (12 Dec 1998) |
| phenoxymethylpenicillin amidohydrolase | <enzyme> Isolated from penicillium chrysogenes; hydrolyses phenoxymethylpenicillin to 6-aminopenicillanic acid (6-apa) Registry number: EC 3.5.1.- Synonym: pmp amidase (26 Jun 1999) |
| phenozygous | Having a narrow cranium as compared with the width of the face, so that when the skull is viewed from above, the zygomatic arches are visible. Origin: G. Phaino, to show, + zygon, yoke (05 Mar 2000) |
| phenpentermine tartrate | A,a,beta-Trimethylphenethylamine;an anorexigenic agent. (05 Mar 2000) |