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isoelectric zone The range of H-ion concentration (pH) over which isoelectric precipitation occurs.
(05 Mar 2000)
isoenergetic Exerting equal force; equally active.
Synonym: isodynamogenic.
(05 Mar 2000)
isoenzyme <biochemistry> Variants of enzymes that catalyse the same reaction, but owing to differences in amino acid sequence can be distinguished by techniques such as electrophoresis or isoelectric focusing.
Different tissues often have different isoenzymes. The sequence differences generally confer different enzyme kinetic parameters that can sometimes be interpreted as fine tuning to the specific requirements of the cell types in which a particular isoenzyme is found.
(15 Oct 1997)
isoenzyme electrophoresis Electrophoretic separation of serum enzymes; separation of lactate dehydrogenase and creatine phosphokinase is commonly used for diagnosis of acute myocardial infarction.
(05 Mar 2000)
isoenzymes One of various structurally related forms of an enzyme, each having the same mechanism but with differing chemical, physical, or immunologically characteristics.
(12 Dec 1998)
isoepoxydon dehydrogenase <enzyme> Interconversion between phyllostine (2-hydroxymethyl-5,6-epoxy-1,4-benzoquinone) and isoepoxydon (4-hydroxy-5,6-epoxycyclohex-2-en-1-one
Registry number: EC 1.-
(26 Jun 1999)
isoerythrolysis Destruction of erythrocytes by isoantibodies.
Origin: iso-+ erythrocyte = G. Lysis, dissolution
(05 Mar 2000)
isoetharine <chemical> Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.
Pharmacological action: adrenergic beta-agonists, bronchodilator agents, sympathomimetic.
Chemical name: 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)butyl)-
(12 Dec 1998)
isoflavone 7-O-glucoside-6''-malonate malonylesterase <enzyme> From roots of chickpea (cicer arietenum)
Registry number: EC 3.1.1.-
Synonym: ifgmm esterase
(26 Jun 1999)
isoflavone synthase <enzyme> Microsomal enzyme from soybeans; converts (2s)-naringenin to genistein and converts (2s)-5,4'-dihydroxflavanone to daidzein; requires NADPH and oxygen; may be a cytochrome p-450-dependent monooxygenase
Registry number: EC 1.14.13.-
Synonym: genistein synthase, naringenin monooxygenase, NADPH-2'-hydroxydaidzein oxidoreductase
(26 Jun 1999)
isoflavone-5-O-methyltransferase <enzyme> Yellow lupin root enzyme catalyses position-specific methylation of the 5-hydroxyl group of a number of isoflavones, has little or no activity with flavones, flavonols, coumarins or phenylpropanoids
Registry number: EC 2.1.1.-
Synonym: isf-methyltransferase
(26 Jun 1999)
isoflavones 3-phenylchromones. Isomeric form of flavones in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.
(12 Dec 1998)
isofluorphate [(CH3)2CH-O]2P(O)F;a toxic cholinergic agent that acts by irreversible inhibition of cholinesterase; an ophthalmic cholinergic agent; also used in biochemical research as an enzyme inhibitor.
Synonym: diisopropyl fluorophosphate.
(05 Mar 2000)
isoflurane <chemical> 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether. A stable, non-explosive inhalation anaesthetic, relatively free from significant side effects.
Pharmacological action: anaesthetics, inhalation.
Chemical name: Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
(12 Dec 1998)
isoflurophate <chemical> Phosphorofluoridic acid bis(l-methylethyl) ester. An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically.
Pharmacological action: cholinesterase inhibitor, miotics, parasympathomimetic, protease inhibitors.
Chemical name: Phosphorofluoridic acid, bis(1-methylethyl) ester
(12 Dec 1998)
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