| end-filling | The use of DNA polymerase to create a blunt end (both strands are the same length and end together) on double-stranded DNA that has a staggered end (one strand is longer than the other so there is a single-stranded section at the end of the molecule). (09 Oct 1997) |
|---|---|
| end-on mattress suture | A vertical mattress suture used for exact skin approximation. (05 Mar 2000) |
| end organ | The special structure containing the terminal of a nerve fibre in peripheral tissue such as muscle, tissue, skin, mucous membrane, or glands. See: ending. (05 Mar 2000) |
| end oxidation | <biochemistry> The last oxidation step in a catabolic pathway. Synonym: terminal oxidation. (05 Mar 2000) |
| end-piece | The terminal part of the tail of a spermatozoon consisting of the axoneme and the flagellar membrane. (05 Mar 2000) |
| end plate | <anatomy, physiology> The area of sarcolemma immediately below the synaptic region of the motor neuron in a neuromuscular junction. most often refers to the end of a nerve fibre against a skeletal muscle fibre, to which it transmits nerve signals. (18 Nov 1997) |
| end plate potential | <physiology> Depolarisation of the sarcolemma as a result of acetylcholine release from the motoneuron causing an influx of sodium ions. The endplate potential is the sum of quantal miniature endplate potentials. Development of the end plate potential is blocked by curare. (18 Nov 1997) |
| end point | <chemistry> It is the completion point during a titration reaction where there are equal amounts of titrant and whatever is being titrated. It is usually evident by the first perceptible alteration of the colour of an added indicator. <immunology> It is the most dilute an antibody or antiserum solution can be while still detectably reacting with the antigen. <statistics> A category of data used to compare the outcome in different arms of a clinical trial. Common endpoints are severe toxicity, disease progression or fall in such surrogate markers as CD4 count, but sometimes death is used as an endpoint. (08 Mar 2000) |
| end-point measurement | Analytical measurement at the end of a chemical reaction, as opposed to making the measurement while the reaction proceeds. (05 Mar 2000) |
| end-point nystagmus | A jerky, physiologic nystagmus occurring in a normal individual when attempts are made to fixate a point at the limits of the field of fixation. Synonym: deviational nystagmus. (05 Mar 2000) |
| end product | <biochemistry> The final product of after a series of reactions with enzymes in a biochemical metabolic pathway has taken place. (09 Oct 1997) |
| end product inhibition | <biochemistry, physiology> The process of the end product of a particular metabolic reaction inhibiting an allosteric enzyme involved in that reaction as the reaction starts again, thus breaking the reaction cycle. (09 Oct 1997) |
| end product repression | Catabolite repression in which the catabolite is an end product of a particular pathway. (05 Mar 2000) |
| end stage | The late, fully developed phase of a disease; e.g., in end-stage renal disease, a shrunken and scarred kidney that may result from a variety of chronic diseases that have become indistinguishable in their effect on the kidney. (05 Mar 2000) |
| end-stage renal disease | <nephrology> A patient with inadequate renal function to support life. Individuals with end-stage disease must rely in kidney dialysis or peritoneal dialysis to survive. End-stage renal disease may be caused by a number of problems including diabetes, sickle cell disease, hypertension and congenital renal disease (polycystic kidney disease). (27 Sep 1997) |