| familial spinal muscular atrophy | Transmitted as autosomal recessive on chromosome 5q. Progressive dysfunction of the anterior horn cells in the spinal cord and brainstem cranial nerves with profound weakness and bulbar dysfunction occurring in the first two years of life. Three groups, based on age of clinical onset, are recognised. Synonym: familial spinal muscular atrophy, Hoffmann's muscular atrophy, infantile muscular atrophy, infantile progressive spinal muscular atrophy, progressive infantile spinal muscular atrophy, Werdnig-Hoffmann disease, Werdnig-Hoffmann muscular atrophy. (05 Mar 2000) |
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| familial splenic anaemia | <disease> A chronic congenital disease of lipid metabolism caused by a deficiency of the beta-glucocerebrosidase enzyme. The defect is most common in Ashkenazi Jews. Clinical features are hepatosplenomegaly (enlargement of liver and spleen) and in severe early onset forms of the disease, with neurological dysfunction. Inheritance: autosomal recessive. (27 Sep 1997) |
| familial tremor | <neurology> A neurologic disorder that runs in families and manifests as tremor which typically increases with purposeful movements. Stimulant use can increase tremor. (27 Sep 1997) |
| familial white folded dysplasia | An autosomal dominant condition of the oral cavity characterised by soft, white or opalescent, thickened and corrugated folds of mucous membrane; other mucosal sites are occasionally involved simultaneously. Synonym: familial white folded dysplasia, oral epithelial nevus. (05 Mar 2000) |
| lipoprotein lipase deficiency, familial | A rare familial condition characterised by massive chylomicronaemia and decreased levels of other lipoproteins. It is due to deficiency of lipoprotein lipase, an alkaline triglyceride hydrolase which catalyses an important step in the extrahepatic removal of triglyceride-rich lipoproteins from the blood. (12 Dec 1998) |
| absorption fever | An elevation of temperature often occurring, without other untoward symptoms, shortly after childbirth, assumed to be due to absorption of uterine discharges through abrasions of the vaginal wall. (05 Mar 2000) |
| acclimating fever | Elevated temperature with malaise that occurs upon working in a very hot environment. (05 Mar 2000) |
| aden fever | <virology> A tropical disease caused by dengue virus (Arbovirus), that is transmitted by the bite of an infected mosquito of the genus Aedes). Four severity grades of the illness are seen: Grade I: fever and constitutional symptoms. Grade II: grade I plus spontaneous bleeding of skin, gums or gastrointestinal tract. Grade III: grade II plus agitation and circulatory failure. Grade IV: profound shock. Grade I infection is seen most frequently in world travelers, where it is usually self-limited and rarely fatal. The other grades are referred to as dengue haemorrhagic fever and are often fatal. Dengue haemorrhagic fever appears to be an infection by one of the other dengue viruses. Prior immunity to a different dengue virus type appears to be important in the development of the more serious haemorrhagic form. Vaccines are available. Protection from mosquitoes is an important preventive measure. (15 Jan 1998) |
| aestivoautumnal fever | <infectious disease> A tropical parasitic disease caused by one of the genus Plasmodium and carried by infected mosquitoes of the genus Anopheles. This parasite uses red blood cells to complete its reproductive cycle. Common symptoms of an attack include high fever, chills, sweats and body aches. (27 Sep 1997) |
| African haemorrhagic fever | Haemorrhagic fever associated with the morphologically similar but antigenically distinct Marburg and Ebola viruses. See: viral haemorrhagic fever. (05 Mar 2000) |
| african swine fever | A usually fatal iridovirus infection of pigs, characterised by fever, cough, diarrhoea, haemorrhagic lymph nodes, and oedema of the gallbladder. (12 Dec 1998) |
| african swine fever-like viruses | An unnamed, unclassified genus of DNA viruses with a single species: african swine fever virus. (12 Dec 1998) |
| african swine fever virus | The lone species of the genus african swine fever-like viruses. The virus causes a fatal disease among domestic pigs in africa and a less virulent infection in europe. The virus is present in soft ticks (ornithodoros moubata), warthogs, or domestic pigs. Originally listed as a species of iridoviridae, the virus exhibits some similarities to poxviridae but its differences warranted placement in a separate genus of an, as yet unknown, family. (12 Dec 1998) |
| African tick fever | A form of haemorrhagic fever distinct from Omsk haemorrhagic fever, occurring in central Russia, transmitted by species of the tick Hyalomma, and caused by Crimean-Congo haemorrhagic fever virus, a member of the Bunyaviridae family; horses are the chief reservoir of human infection; characterised by abrupt onset, high fever, headache, myalgia, widespread petechial haemorrhagic lesions, gastrointestinal bleeding, high fatality rate. Synonym: African tick fever. (05 Mar 2000) |
| algid pernicious fever | A pernicious malarial attack in which the patient presents symptoms of collapse and shock. (05 Mar 2000) |