| DNA-dependent ATPase-endonuclease | <enzyme> Atpase and endonuclease are part of a single protein from phage t4 infected E coli; atpase is activated by duplex, single-stranded or supercoiled DNA Registry number: EC 3.1.21.- Synonym: atpase-endonuclease (26 Jun 1999) |
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| DNA diagnosis | <molecular biology> The use of DNA polymorphisms to detect the presence of a disease gene. (09 Oct 1997) |
| DNA diagnostics | Identifying foetuses or infants afflicted with hereditary diseases or conditions, and carriers of recessive disorders by means of DNA analysis. See: DNA markers, familial screening, prenatal screening. Synonym: genetic testing. (05 Mar 2000) |
| DNA-directed RNA polymerase | <enzyme> A group of enzymes that catalyses DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesised. Chemical name: Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) Registry number: EC 2.7.7.6 (12 Dec 1998) |
| DNA-driven reaction | <molecular biology> A lab technique to mark highly-repeated DNA sequences with a radioactive RNA tracer, by having a much larger amount of complementary DNA molecules than radioactive RNA tracer molecules. (09 Oct 1997) |
| DNA duplex | <molecular biology> The double-stranded DNA molecule, which has a double helix (usually right-handed) structure. (09 Oct 1997) |
| DNA entry nuclease | <chemical> Mw 75kda; from membranes of competent bacillus subtilis cells; shows DNA-binding and nuclease activity; believed to be involved in entry of DNA into competent b subtilis cells (26 Jun 1999) |
| DNA excision | <molecular biology> The removal of a damaged segment of a DNA molecule by a group of DNA repair enzymes in order to repair the molecule. (09 Oct 1997) |
| DNA filter assay | <molecular biology> A lab technique used to identify the complementary base sequences of DNA. It involves immobilising the DNA on a filter and putting it in a solution that contains radioactively-labelled probe DNA or RNA molecules. (09 Oct 1997) |
| DNA fingerprint | <molecular biology> The unique pattern of DNA fragments identified by Southern hybridisation (using a probe that binds to a polymorphic region of DNA) or by polymerase chain reaction (using primers flanking the polymorphic region). (09 Oct 1997) |
| DNA fingerprinting | <molecular biology> See restriction fragment length polymorphism. (18 Nov 1997) |
| DNA footprinting | <molecular biology> Technique for identifying the recognition site of DNA binding proteins: See: footprinting. (18 Nov 1997) |
| DNA fragmentation | Endonucleolytic cleavage of genomic DNA into oligonucleosomal fragments at internucleosomal sites. DNA fragmentation along with chromatin condensation are considered the hallmarks of apoptosis. (12 Dec 1998) |
| DNA, fungal | Deoxyribonucleic acid that makes up the genetic material of fungi. (12 Dec 1998) |
| DNA gap | A localised loss of one of the two strands in the double helix of DNA. (05 Mar 2000) |