| dihydrofolate reductase |
[EC 1.5.1.3] an enzyme of the oxidoreductase class that catalyzes the reduction of dihydrofolate to tetrahydrofolate, using NADPH as an electron donor. The reaction produces reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. Deficiency of the enzyme may be a cause of megaloblastic anemia responsive to therapy with reduced forms of folic acid. Abbreviated DHFR.
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| dihydrofolic acid |
any of the folic acids in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms.
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| dihydroindolone |
any of a class of structurally related antipsychotic agents; the prototype is molindone.
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| dihydrol |
the associated water molecule, (H2O)2.
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| dihydrolipoamide |
the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor.
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