| 11β-hydroxylase deficiency |
an autosomal recessive disorder of steroidogenesis in which deficiency of steroid 11β-monooxygenase causes classic and nonclassic forms of one type of congenital adrenal hyperplasia (type IV). In the classic (hypertensive) form, the enzyme deficiency results in increased levels of cortisol precursors such as 11-deoxycortisol and the salt-retaining hormone 11-deoxycorticosterone, and decreased cortisol and aldosterone synthesis. Clinical manifestations include hypertension and, due to increased androgens, female pseudohermaphroditism and postnatal virilization of both sexes. The nonclassic (late onset) form is milder, and patients are frequently normotensive. See table at hyperplasia.
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| 11β-hydroxysteroid dehydrogenase |
[EC 1.1.1.146] an enzyme of the oxidoreductase class that catalyzes the reversible hydrogenation-dehydrogenation reaction between cortisone and cortisol.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 11β-hydroxysteroid dehydrogenase deficiency |
an enzyme deficiency resulting in excessive excretion of cortisol metabolites in the urine and an excess of mineralocorticoids in the kidneys, which causes potassium excretion (hypokalemia), sodium retention (hypernatremia), and hypertension.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 11-cis r. |
a retinal isomer that combines with opsins to form photoreceptive molecules, in the rods combining with scotopsin to form rhodopsin and in the cones combining with photopsins to form several iodopsins. In the presence of light, it is converted to the all-trans isomer.
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| 11-d. acetate |
see under desoxycorticosterone.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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