| non-specific | 1. Not due to any single known cause, as to a particular pathogen. 2. Not directed against a particular agent, but rather having a general effect, as non-specific therapy. (18 Nov 1997) |
|---|---|
| non-specific anergy | A reduction of the normal or usual immunologic responses because of unrelated intervening disease. Synonym: non-specific anergy. (05 Mar 2000) |
| non-specific cholinesterase | <enzyme> An enzyme that breaks down acetylcholine tostop its action. (22 May 1997) |
| non-specific protein | A protein substance that elicits a response not mediated by specific antigen-antibody reaction. (05 Mar 2000) |
| non-specific system | <physiology> A physiological term denoting that part of the brainstem reticular formation that plays a central role in the organism's bodily and behavorial alertness. It extends as a diffusely organised neural apparatus through the central region of the brainstem into the subthalamus and the intralaminar nuclei of the thalamus; by its ascending connections it affects the function of the cerebral cortex in the sense of behavioural responsiveness; its descending (reticulospinal) connections transmit its activating influence upon bodily posture and reflex mechanisms (e.g., muscle tonus), in part by way of the gamma motor neurons. See: reticular formation. Synonym: non-specific system. (05 Mar 2000) |
| non-specific therapy | The injection of a foreign protein, typhoid vaccine, etc., to induce fever in the treatment of certain diseases, especially those of a parasyphilitic nature. Synonym: phlogotherapy. (05 Mar 2000) |
| non-specific urethritis | Urethritis not resulting from gonococcal, chlamydial, or other specific infectious agents. Synonym: simple urethritis. (05 Mar 2000) |
| non-specific vaginitis | bacterial vaginosis |
| sugar-non-specific nuclease | <enzyme> An exocytoplasmic sugar-non-specific nuclease that is able to degrade linear or covalently closed circular double-stranded DNA as well as single-stranded DNA or RNA; from cyanobacterium anabaena; mw 29 kD; amino acid sequence has been determined Registry number: EC 3.1.- Synonym: nuca gene product, anabaena (26 Jun 1999) |
| deoxyribonucleases, type III site-specific | <enzyme> Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as atpases. They exist as complexes with modification methylases of similar specificity. The systems recognise specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.5 (12 Dec 1998) |
| deoxyribonucleases, type II site-specific | <enzyme> Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognise specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.4 (12 Dec 1998) |
| deoxyribonucleases, type I site-specific | <enzyme> Enzyme systems containing three different subunits and requiring ATP, s-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent atpases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognise specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.3 (12 Dec 1998) |
| IgA-specific serine endopeptidase | <enzyme> Extracellular microbial enzymes whose only substrate is human IgA of the iga1 subclass; cleave the immunoglobulin at a specific internal prolyl-threonyl peptide bond in the heavy chain to yield intact faba and fca fragments; consider also EC 3.4.24.13 Registry number: EC 3.4.21.72 Synonym: immunoglobulin a(1) protease, iga1 protease, immunoglobulin a1 protease, IgA protease (26 Jun 1999) |
| organ-specific | Denoting or pertaining to a serum produced by the injection of the cells of a certain organ or tissue that, when injected into another animal, destroys the cells of the corresponding organ. (05 Mar 2000) |
| organ-specific antigen | A heterogenetic antigen with organ specificity; e.g., in addition to species-specific antigen, kidney of one species contains antigen that is identical to that in kidney of other species. Synonym: tissue-specific antigen. (05 Mar 2000) |