| rhG-CSF | recombinant human granulocyte colony-stimulating factor |
|---|---|
| rhGM-CSF | recombinant human granulocyte macrophage colony-stimulating factor |
| rH-TNF | recombinant human tumor necrosis factor |
| rh-tPA | recombinant tissue plasminogen activator |
| rHuEpo | recombinant human erythropoietin |
| bacteriophage T7 induced DNA polymerase | <enzyme> Complex of two proteins, phage gene 5 protein and E coli thioredoxin Registry number: EC 2.7.7.- Synonym: t7 phage DNA polymerase, sequenase, t7 DNA polymerase, thermo sequenase (26 Jun 1999) |
|---|---|
| base in DNA | A unit of the DNA. There are 4 bases: adenine (A), guanine (G), thymine (T), and cytosine (C). The sequence of bases (for example, CAG) is the genetic code. (12 Dec 1998) |
| beta-DNA | <molecular biology> The normal form of DNA found in organisms, which exists as a right-handed helix. (09 Oct 1997) |
| blunt-end DNA | <molecular biology> A fragment of a DNA molecule in which the ends of both strands are even with each other rather than one strand being longer than the other. (09 Oct 1997) |
| blunt-ended DNA | Double-stranded DNA in which at least one of the ends has no unpaired bases. (05 Mar 2000) |
| vaccines, DNA | Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers. (12 Dec 1998) |
| Rad3 ATPase-DNA helicase | <enzyme> Can unwind duplex regions as short as 11 base pairs in a partially duplex circular DNA substrate; on partially duplex linear substrates, the enzyme has a strict 5'--3' polarity with respect to the single strand to which it binds; nicked circular DNA is not utilised; from saccharomyces cerevisiae Registry number: EC 3.6.1.- Synonym: rad3 protein (26 Jun 1999) |
| palindromic DNA | A segment of DNA in which the sequence is symmetrical about its midpoint. (05 Mar 2000) |
| random amplification of polymorphic DNA | <molecular biology> A term originally invented by polymer chemists to describe a disordered tangle of a linear polymer chain with curved sections. In DNA parlance the random coil refers to the structure that results from melting or other forms of separation of the double helix, i.e. Helix coil transition. (18 Nov 1997) |
| genomic DNA | <molecular biology> The DNA which is found in the organisms genome and is passed on to offspring as information necessary for survival. The phrase is used to distinguish between other types of DNA, such as found within plasmids. (09 Oct 1997) |
| relaxed DNA | <molecular biology> DNA that isn't supercoiled. (09 Oct 1997) |
| repetitive DNA | <molecular biology> Nucleotide sequences in DNA that are present in the genome as numerous copies. Originally identified by the C0t_ value derived from kinetic studies of DNA renaturation. These sequences are not thought to code for polypeptides. One class of repetitive DNA, termed highly repetitive DNA, is found as short sequences, 5-100 nucleotides, repeated thousands of times in a single long stretch. It typically comprises 3-10% of the genomic DNA and is predominantly satellite DNA. Another class, which comprises 25-40% of the DNA and termed moderately repetitive DNA, usually consists of sequences about 150 to 300 nucleotides in length dispersed evenly throughout the genome and includes Alu sequences and transposons. (18 Nov 1997) |
| replication, DNA | A wondrous complex process whereby the ( parent ) strands of DNA in the double helix are separated and each one is copied to produce a new ( daughter ) strand. This process is said to be semi-conservative since one of each parent strand is conserrved and remains intact after replication has taken place. (12 Dec 1998) |
| melting temperature of DNA | That temperature at which, under a given set of conditions, double-stranded DNA is changed (50%) to single-stranded DNA; under standard conditions, the base composition of the DNA can be estimated from the denaturation temperature, since the greater the denaturation temperature, the greater the guanine-plus-cytosine content (i.e., GC content) of the DNA. Synonym: melting temperature of DNA. (05 Mar 2000) |
| chimeric DNA | <molecular biology> A molecule of DNA that has resulted from recombination, or has resulted from DNA from two sources being spliced together. (05 Jan 1998) |