| 영문 | Paget's disease | 한글 | 파제트병 |
|---|---|---|---|
| 설명 | 1. 뼈파제트병. 변형성 뼈염. 뼈흡수 후 뼈형성이 반복적으로 과도하게 일어나는 것으로, 새롭게 형성된 뼈는 무질서하고 구조적으로 견고하지 못하다. 뼈흡수의 증가가 반복되고 이어서 과잉보수를 꾀하여 약하고 변형된 뼈의 부피가 증가되는 것을 특징으로 하는 뼈병이다. 궁둥뼈의 만곡, 편평뼈의 변형을 일으키고, 동통 및 병적 골절을 수반한다. 2. 유방파제트병. 젖꽃판 및 젖꼭지의 염증성 암성 질병으로서 보통은 젖샘 및 유방 깊은 곳의 암을 동반한다. 보통 중년부인에게 발생한다. |
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| 영문 | Parkinson disease | 한글 | 파킨슨병 |
|---|---|---|---|
| 설명 | 나이든 사람에게 발생하는 신경계의 퇴행병이다. 주로 운동을 담당하는 중간뇌부위가 침범된다. 원인은 바이러스, 약물, 혹은 동맥경화증 등으로 알려진 경우도 있으나, 원인을 알 수 없는 경우가 많다. 증상은 가면얼굴, 쓰러질 것 같은 걸음걸이, 손떨림, 근육의 강직, 앞으로 기울어진 자세 등임. 치료는 특별한 것이 없으며, 대개 보존적 치료(완치를 목적으로 하지 않고 단지 환자의 생활을 보조해주는 정도의 치료)를 시행한다. 최근, 죽은 태아의 뇌를 이식하는 뇌 이식술에 의한 치료효과가 높다는 보고가 있다. |
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| 영문 | endemic disease | 한글 | 풍토병 |
|---|---|---|---|
| 설명 | 인간사회에 항상 존재하지만 특수한 기후나 토질로 인하여 특정지역에만 존재하는 사망률이 낮고, 임상적으로도 드물게 볼 수 있는 병. 특히 그 토지의 풍토-기후-생물-토양 등의 자연환경과 그 지방 주민의 풍속-습관-인습 등이 복잡하게 얽혀서 생긴 특수한 병을 가리킨다. 일반적으로 그 지방 주민의 사망률은 그다지 높지 않지만 근절되기 어려운 것이 특징이다. 지방병이라는 말은 어느 지방에 한정하여 볼 수 있는 병이라는 점에서는 같지만, 풍토환경과 밀접한 관계가 있다는 데서 보면 풍토병이라는 용어가 적절하다. 국내적으로는 쯔쯔가무시병, 야생토끼병, 렙토스피라증 등이 알려져 있고, 세계적으로는 말라리아, 황열, 페트스, 일본주혈흡충증 등이 알려져 있다. |
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| 영문 | Hodgkin's disease | 한글 | 호지킨병 |
|---|---|---|---|
| 설명 | 악성림프종의 한 형태이다. 호지킨병은 방사선 치료에 대단히 예민해서 충분한 양의 방사선으로 완전한 근치적 치료가 가능하다. |
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| ED | early-decision [applicant]; early differentiation; ectodermal dysplasia; ectopic depolarization; eff... |
|---|---|
| GSD | genetically significant dose; Gerstmann-Straussler disease; glutathione synthetase deficiency; glyco... |
| SCD | scleroderma; service-connected disability; sickle-cell disease; spinocerebellar degeneration; subacu... |
| ECG | Electro-Cardio-Graphy(-Gram); 심전도 = EKG 1. Conducting System Structu... |
| AHD | acquired hepatocerebral degeneration; acute heart disease; antihyaluronidase; antihypertensive drug;... |
| protein s deficiency | An autosomal dominant disorder showing decreased levels of plasma protein s antigen or activity, associated with venous thrombosis and pulmonary embolism. Protein s is a vitamin k-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein c (also a vitamin k-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein c deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (12 Dec 1998) |
|---|---|
| prothrombin deficiency | A congenital or acquired disorder of blood clotting where there is a deficiency of factor II (prothrombin), one of 20 necessary plasma proteins for normal blood coagulation. Acquired factor II deficiency may result from vitamin K deficiency, severe liver disease and anticoagulant drugs. Symptoms include abnormal bleeding, nosebleeds, abnormal menstrual bleeding, easy bruising and umbilical cord bleeding at birth. Treatment involves the infusion of fresh frozen plasma. Vitamin K may be administered in select cases. (27 Sep 1997) |
| proximal femoral focal deficiency | A congenital defect in which variable portions of the upper end of the femur are reduced or absent. (05 Mar 2000) |
| pseudocholinesterase deficiency | An autosomal dominant disorder manifested by exaggerated responses to drugs ordinarily hydrolyzed by serum pseudocholinesterase (e.g., succinylcholine); believed to entail production of a variant enzyme that is less active than the normal enzyme in hydrolyzing appropriate substrates, but also abnormally resistant to the effects of anticholinesterases. (05 Mar 2000) |
| secondary antibody deficiency | Immunodeficiency in which there is no evident defect in the lymphoid tissues, but rather hypercatabolism or loss of immunoglobulins such as occurs in familial idiopathic hypercatabolic hypoproteinaemia or in defects associated with the nephrotic syndrome. Synonym: secondary agammaglobulinaemia, secondary antibody deficiency, secondary hypogammaglobulinaemia. (05 Mar 2000) |
| selective immunoglobulin A deficiency | <immunology> An inherited disorder in which there is a markedly reduced or absent IgA, resulting in immature IgA-bearing B-cells. (05 Mar 2000) |
| selenium deficiency | deficiency of the essential mineral selenium causes keshan disease, a fatal form of cardiomyopathy (disease of the heart muscle) first observed in keshan province in china and since found elsewhere. According to the national academy of sciences, the recommended dietary allowances of selenium are 70 milligrams per day for men and 55 milligrams per day for women. Food sources of selenium include seafoods, some meats such as kidney and liver, and some grains and seeds (12 Dec 1998) |
| pyridoxine deficiency | A nutritional condition produced by a deficiency of pyridoxine in the diet, characterised by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhoea, anaemia, and seizures. Increasingly recognised as a cause is prolonged therapy with certain medications, among them isoniazid, cycloserine, and l-dopa. (12 Dec 1998) |
| pyruvate carboxylase deficiency | An autosomal recessive pyruvate metabolism disorder resulting from absent or deficient expression of pyruvate carboxylase activity. Decreased production of oxaloacetate leads to decreased gluconeogenesis, thereby causing fasting hypoglycaemia, lactic acid acidosis, and decreased synthesis of amino acid neurotransmitters. Clinical presentations include acidosis, ataxia, mental retardation; sometimes co-occurs with leigh disease. (12 Dec 1998) |
| pyruvate dehydrogenase complex deficiency | An autosomal recessive pyruvate metabolism disorder resulting from deficient enzyme activity in one of several proteins of pyruvate dehydrogenase complex, resulting in deficiency of acetyl CoA. Deficiency in acetyl CoA product reduces the synthesis of acetylcholine, thereby causing neurological abnormalities. Clinical presentations include lactic acidosis, mental retardation, and ataxia. (12 Dec 1998) |
| pyruvate kinase deficiency | A disorder in which there is a deficiency of pyruvate kinase in red blood cells; characterised by haemolytic anaemia varying in degree from one patient to another; autosomal recessive inheritance. (05 Mar 2000) |
| hypoxanthine guanine phosphoribosyltransferase deficiency | A sex-linked inherited metabolic disorder; complete deficiency results in Lesch-Nyhan syndrome; incomplete deficiency is associated with acute gouty arthritis and renal stones. (05 Mar 2000) |
| steroid sulfatase deficiency | A form of ichthyosis, due to 3-beta-hydroxysteroidsulfate sulfatase deficiency, that appears at birth or in early infancy and affects males; characterised by scaling predominantly on the neck and trunk but not on the palms and soles; histologically, there is hyperkeratosis, a granular layer in the epidermis, and normal epidermal cell turnover. Synonym: steroid sulfatase deficiency. (05 Mar 2000) |
| niacin deficiency | <biochemistry> A niacin deficiency disease (pellagra) caused by improper diet and characterised by skin lesions, gastrointestinal disturbances and nervousness. Depression, dermatitis, dementia and diarrhoea are common symptoms. (27 Sep 1997) |
| debrancher deficiency | Type of glycogen storage disease, due to deficiency of amylo-1,4-1,6-transglucosidase (brancher enzyme). Synonym: brancher deficiency glycogenosis, debrancher deficiency. (05 Mar 2000) |