| hamartoma syndrome, multiple | A hereditary disease characterised by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Papules of the face and oral mucosa are the most characteristic lesion. Other changes occur in the skin, in the thyroid, the breast, the gastrointestinal system, and the nervous system. (12 Dec 1998) |
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| pregnancy, multiple | The condition of bearing two or more foetuses simultaneously. (12 Dec 1998) |
| hereditary multiple exostoses | A disturbance of enchondral bone growth in which multiple, generally benign osteochondromas of long bones appear during childhood, commonly with shortening of the radius and fibula; the ill-effects are usually mechanical but malignant change is rare; autosomal dominant inheritance. Synonym: diaphysial aclasis, hereditary deforming chondrodystrophy, multiple exostosis, osteochondromatosis. (05 Mar 2000) |
| hereditary multiple trichoepithelioma | <tumour> Multiple small benign nodules, occurring mostly on the skin of the face, derived from basal cells of hair follicles enclosing small keratin cysts; frequent autosomal dominant inheritance. Synonym: acanthoma adenoides cysticum, Brooke's tumour, epithelioma adenoides cysticum, hereditary multiple trichoepithelioma. Origin: tricho-+ epithelioma (05 Mar 2000) |
| sclerosis, multiple | The National Multiple Sclerosis Society says of ms that it is a disease that randomly attacks your central nervous system, wearing away the control you have over your body. Symptoms may range from numbness to paralysis and blindness. The progress, severity and specific symptoms cannot be foreseen. You never know when attacks will occur, how long they will last, or how severe they will be. most people are diagnosed with ms between the ages of 20 and 40. In medical terms, ms involves demyelinization of the white matter sometimes extending into the gray matter. Demyelinization is loss of myelin, the coating of nerve fibres composed of lipids (fats) and protein that serves as insulation and permits efficient nerve fibre conduction. The white matter is the part of the brain which contains myelinated nerve fibres and appears white, whereas the gray matter is the cortex of the brain which contains nerve cell bodies and appears gray. When myelin is damaged in ms, nerve fibre conduction is faulty or absent. Impaired bodily functions or altered sensations associated with those demyelinated nerve fibres give rise to the symptoms of ms. Recent research (1998) has also identified nerve cell death as part of the nervous system injury in ms. (12 Dec 1998) |
| psychotherapy, multiple | The use of more than one therapist at one time in individual or group psychotherapy. (12 Dec 1998) |
| neoplasms, multiple primary | Two or more abnormal growths of tissue occurring simultaneously. The neoplasms are histologically different and may be found in the same or different sites. (12 Dec 1998) |
| drug resistance, multiple | Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. (12 Dec 1998) |
| exostoses, multiple hereditary | Hereditary disorder transmitted by an autosomal dominant gene and characterised by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation. (12 Dec 1998) |
| familial multiple endocrine adenomatosis | The presence of functioning tumours in more than one endocrine gland, commonly the pancreatic islets and parathyroid glands, which may be associated with Zollinger-Ellison syndrome; dominant inheritance. Synonym: multiple endocrine adenomatosis. (05 Mar 2000) |
| law of multiple proportions | The relative weights in which two substances form a chemical union singly with a third are the same as, or simple multiples of, those in which they unite with each other; a corollary of the law of definite proportions. Synonym: law of multiple proportions. (05 Mar 2000) |
| lipomatosis, multiple symmetrical | Multiple circumscribed or encapsulated lipomas which may be distributed symmetrically or haphazardly or which may form a collar around the neck. (12 Dec 1998) |
| Abbott's method | A method of treatment of scoliosis by use of a series of plaster jackets applied after partial correction of the curvature by external force. (05 Mar 2000) |
| Abell-Kendall method | A standard method for estimation of total serum cholesterol involving saponification of cholesterol ester by hydroxide, extraction with petroleum ether, and colour development with acetic anhydride-sulfuric acid; the method avoids interference by bilirubin, protein, and haemoglobin. (05 Mar 2000) |
| activated sludge method | A method of sewage disposal in which the sewage is treated with 15% bacterially active, liquid sludge, which is produced by repeated vigorous aeration of fresh sewage to form floccules or sediment; when this flocculation process is complete, the resulting activated sludge contains large numbers of bacteria, together with yeasts, molds, and protozoa, which actively effect the oxidation of organic compounds; this mixture is piped to a sedimentation tank, the effluent from which is completely treated sewage. (05 Mar 2000) |