| epitopes, t-lymphocyte | Antigenic determinants recognised and bound by the T-cell receptor. Epitopes recognised by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen. (12 Dec 1998) |
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| tumour-infiltrating lymphocyte | <haematology, oncology> Special cancer-fighting cells of the immune system found in tumours. In a type of experimental therapy, scientists harvest these cells from the tumour, grow them in a laboratory and then return them to the patient with the hope of the cells destroying the tumour. These cells can be collected from the site of a tumour and exposed to IL-2 in vitro. When these cells are injected back into the tumour bearing host, they will specifically kill the tumour from which they originated. (05 Mar 2000) |
| lymphocyte | <haematology> White cell of the blood that are derived from stem cells of the lymphoid series. Two main classes are recognised, T and B lymphocytes, the latter responsible (when activated) for production of antibody, the former subdivided into subsets (helper, suppressor, cytotoxic T-cells) and responsible both for cell-mediated immunity and for stimulating B-cells. (18 Nov 1997) |
| lymphocyte activation | <haematology> The change in morphology and behaviour of lymphocytes exposed to a mitogen or to an antigen to which they have been primed. The result is the production of lymphoblasts, cells that are actively engaged in protein synthesis and that divide to form effector populations. Should not be confused with transformation of the type associated with oncogenic viruses and activation is therefore perhaps a better term. (18 Nov 1997) |
| lymphocyte cooperation | T-cell enhancement of the B-cell response to thymic-dependent antigens. (12 Dec 1998) |
| lymphocyte count | A count of the number of lymphocytes in the blood. (12 Dec 1998) |
| lymphocyte depletion | Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation. (12 Dec 1998) |
| lymphocyte function associated antigen | A member of the integrin family that is expressed on all leukocytes and binds to ICAM-1 and ICAM-2 on a variety of cells. (05 Mar 2000) |
| lymphocyte function-associated antigen-1 | A heterodimer molecule widely expressed on cells of haematopoietic origin. Cd11a antigen comprises the alpha chain and the CD18 antigen (antigens, CD18) the beta chain. Lfa-1 is a major receptor of T-cells, B-cells, and granulocytes. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Intracellular adhesion molecule-1 (icam-1) has been defined as a ligand for lfa-1. (12 Dec 1998) |
| lymphocyte-oriented kinase | <enzyme> An ste20-like protein kinase; genbank d89728 Registry number: EC 2.7.10.- Synonym: lok gene product (26 Jun 1999) |
| lymphocyte specific protein tyrosine kinase p56(lck) | <enzyme> This enzyme is a lymphoid specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the il-2 receptor, and is thought to be involved in the earliest steps of tcr-mediated T-cell activation. Registry number: EC 2.7.11.- (12 Dec 1998) |
| lymphocyte subsets | A classification of lymphocytes based on structurally or functionally different populations of cells. (12 Dec 1998) |
| lymphocyte transformation | <haematology> The change in morphology and behaviour of lymphocytes exposed to a mitogen or to an antigen to which they have been primed. The result is the production of lymphoblasts, cells that are actively engaged in protein synthesis and that divide to form effector populations. Should not be confused with transformation of the type associated with oncogenic viruses and activation is therefore perhaps a better term. (18 Nov 1997) |
| lymphocyte transfusion | The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor. (12 Dec 1998) |
| anamnestic response | <immunology> Archaic term now replaced by such terms as secondary immune response, immune memory. (18 Nov 1997) |