| lymphoma, non-hodgkin | Any of a group of malignant tumours of lymphoid tissue that differ from hodgkin disease, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumours is the absence of giant reed-sternberg cells, a characteristic of hodgkin's disease. (12 Dec 1998) |
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| lymphoma, small-cell | A B-cell lymphoma presumably representing a tumour of interfollicular B-lymphocytes that may be functional. Those that are secrete identical immunoglobulin molecules. (12 Dec 1998) |
| lymphoma, small cleaved-cell, diffuse | An intermediate-grade malignant lymphoma in which the neoplastic cells (B-lymphocytes) exhibit variability in size, configuration, and degree of differentiation. The cells have distinctive nuclei, irregular in shape, with marked indentations and angularity. (12 Dec 1998) |
| lymphoma, small cleaved-cell, follicular | A low-grade malignant lymphoma of predominantly follicular pattern. Follicles are of relatively uniform size and shape and the cells are usually somewhat larger than normal lymphocytes. Nuclei are irregular with prominent indentations and cytoplasm can rarely be identified. Cells exhibiting these characteristics are often called centrocytes. (12 Dec 1998) |
| lymphoma, small noncleaved-cell | A high-grade malignant lymphoma that includes both burkitt tumour (burkitt lymphoma) and other lymphomas previously designated undifferentiated non-burkitt type. Nuclei in burkitt tumour are round to ovoid and uniform in size. The non-burkitt type exhibits greater nuclear variation and less evidence of cellular maturation with a correspondingly lesser degree of differentiation. (12 Dec 1998) |
| lymphoma, T-cell | A group of heterogeneous lymphoid tumours representing malignant transformations of T-lymphocytes. (12 Dec 1998) |
| lymphoma, T-cell, cutaneous | A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. Mycosis fungoides and sezary syndrome are the best characterised of these disorders. (12 Dec 1998) |
| lymphoma, T-cell, peripheral | A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (lymphoma, large-cell, immunoblastic), this group's unique features warrant separate treatment. (12 Dec 1998) |
| lymphoma, undifferentiated | A form of lymphoma in which relatively large stem cells with large nuclei, pale, scanty cytoplasm, and indistinct borders are predominant. The cells are undifferentiated, i.e., show no morphologic evidence of maturation toward lymphocytes or histiocytes. (12 Dec 1998) |