| Friend leukaemia virus | A murine leukaemia virus producing leukaemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects dba/2 and swiss mice. (12 Dec 1998) |
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| Friend murine leukaemia virus | <virology> Murine leukaemia virus isolated by Charlotte Friend in 1956 whilst attempting to transmit the Erlich ascites tumour by cell free extracts. Causes an unusual erythroblastosis like leukaemia, in which anaemia is accompanied by large numbers of nucleated red cells in blood. does not carry a host derived oncogene, but seems to induce tumours by proviral insertion into specific regions of host genome. (18 Nov 1997) |
| leukaemia | <haematology> An acute or chronic disease of unknown cause in man and other warm blooded animals that involves the blood forming organs, is characterised by an abnormal increase in the number of leucocytes in the tissues of the body with or without a corresponding increase of those in the circulating blood and is classified according of the type leucocyte most prominently involved. (18 Nov 1997) |
| leukaemia, accelerated phase of | Refers to chronic myelogenous leukaemia that is progressing. The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase, but not as high as in the blast phase. (12 Dec 1998) |
| leukaemia, calla-positive | Acute leukaemia in which lymphocytes are positive for the common acute lymphoblastic leukaemia antigen (calla). (12 Dec 1998) |
| leukaemia cutis | Yellow-brown, red, blue-red, or purple, sometimes nodular lesions associated with diffuse infiltration of leukaemic cells in the skin; the involvement may be diffuse and generalised, i.e., so-called universal leukaemia cutis, or it may be localised. (05 Mar 2000) |
| leukaemia, erythroblastic, acute | A myeloproliferative disorder characterised by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood. (12 Dec 1998) |
| leukaemia, experimental | Leukaemia induced experimentally by administration of various leukemogenic agents, viruses, radiation or transplantation. (12 Dec 1998) |
| leukaemia, feline | A neoplastic disease of cats frequently associated with feline leukaemia virus infection. (12 Dec 1998) |
| leukaemia, hairy cell | A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukaemia; it is characterised by an insidious onset, splenomegaly, anaemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow. (12 Dec 1998) |
| Leukaemia inhibitory factor | <growth factor> Polypeptide growth factor or cytokine with wide range of activities. Regulates growth and differentiation of primordial germ cells and embryonic stem cells but has effects on peripheral neurons, osteoblasts, adipocytes and various cells of the myeloid lineage. Given to adult animals induces weight loss, behavioural disorders and bone abnormalities. Many of the effects of LIF in vitro can be mimicked by IL-6, oncostatin M and ciliary neurotrophic factor, all of which interact indirectly with gp130, a shared tranducer subunit. (18 Nov 1997) |
| leukaemia l5178 | An experimental lymphocytic leukaemia of mice. (12 Dec 1998) |
| leukaemia, lymphocytic | Leukaemia associated with hyperplasia and overactivity of the lymphoid tissue. There are increased numbers of circulating malignant lymphocytes and lymphoblasts. (12 Dec 1998) |
| leukaemia, masT-cell | A disorder characterised by the presence of large numbers of tissue mast cells in the peripheral blood. (12 Dec 1998) |
| leukaemia, megakaryocytic, acute | Nonlymphocytic leukaemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. Myelofibrosis or increased bone marrow reticulin is common. (12 Dec 1998) |