| large cell l. |
any of several types of lymphoma characterized by formation of malignant large lymphocytes in a diffuse pattern; some varieties contain exclusively one type of cell, such as lymphoblasts or cleaved or uncleaved follicular center cells, and others have a mixture of cells, sometimes including ones that cannot be characterized as to lineage.
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| large cell, immunoblastic l. |
a type of non-Hodgkin's lymphoma characterized by large lymphoblasts (immunoblasts) that resemble histiocytes rather than follicular center cells, and have a diffuse pattern of infiltration; the cell population may be exclusively B or T lymphoblasts or a mixture. It has a high degree of malignancy and often grows rapidly. Tumors of predominantly B cells are often associated with a preexisting immunologic disorder such as Sjögren's syndrome, systemic lupus erythematosus, or Hashimoto's thyroiditis, or with an immunosuppressed state.
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| large cleaved c. |
large cleaved follicular center c.
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| large cleaved cell l. |
a type of non-Hodgkin's lymphoma characterized by the formation of malignant large cleaved follicular center cells; there are both follicular and diffuse varieties. Because of the wide variety of prognostic levels and the existence of tumors with several types of cells, these tumors have been divided among several different groups of follicular and diffuse lymphomas.
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| large granular l.’s |
lymphocytes marked by the presence of large granules visible by light microscopy, responsible for most natural killer cell activity.
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