| bronchiolo-alveolar carcinoma | <tumour> A carcinoma, thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli; involvement may be uniformly diffuse and massive, or nodular, or lobular; microscopically, the neoplastic cells are cuboidal or columnar and form papillary structures; mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells; metastases in regional lymph nodes, and even in more distant sites, are known to occur, but are infrequent. Synonym: alveolar cell carcinoma, bronchiolar adenocarcinoma, bronchiolo-alveolar carcinoma, bronchioloalveolar adenocarcinoma. (05 Mar 2000) |
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| bronchogenic carcinoma | <tumour> Squamous cell or oat cell carcinoma that arises in the mucosa of the large bronchi and produces a persistent productive cough or haemoptysis; local growth causes bronchial obstruction and is observed radiologically as an enlarging lung mass; malignant tumour cells can be detected in the sputum, and they metastasize early to the thoracic lymph nodes and to the brain, adrenal glands, and other organs via the bloodstream. (05 Mar 2000) |
| carcinoma | <oncology> A malignant new growth that arises from epithelium, found in skin or, more commonly, the lining of body organs, for example: breast, prostate, lung, stomach or bowel. Carcinomas tend to infiltrate into adjacent tissue and spread (metastasize) to distant organs, for example: to bone, liver, lung or the brain. Origin: Gr. Karkinoma from karkinos = crab, cancer (16 Dec 1997) |
| carcinoma 256, walker | A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (12 Dec 1998) |
| carcinoma, acinar cell | A malignant tumour arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (latin racemosus, full of clusters) refers, as does acinar (latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumour appears in all age groups and is most common in women. (12 Dec 1998) |
| carcinoma, adenoid cystic | Carcinoma characterised by bands or cylinders of hyalinised or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumours occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (12 Dec 1998) |
| carcinoma, adenosquamous | A mixed adenocarcinoma and squamous cell or epidermoid carcinoma. (12 Dec 1998) |
| carcinoma, adrenal cortical | A malignant neoplasm of adrenal cortical cells demonstrating partial or complete histological and functional differentiation. They are rare, comprising between only 0.05% and 0.2% of all cancers. Women develop functional adrenal cortical carcinomas more commonly than men, but men develop nonfunctioning ones more often than women. Hypercortisolism is the most common presentation for this cancer. Virilism and cushing's syndrome may also result. (12 Dec 1998) |
| carcinoma, basal cell | A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (12 Dec 1998) |
| carcinoma, basosquamous | A skin carcinoma that histologically exhibits both basal and squamous elements. (12 Dec 1998) |
| carcinoma, bronchogenic | A cancer of the lung, so-called because it arises from the epithelium of the bronchial tree. It is not a histologic designation despite the name. (12 Dec 1998) |
| carcinoma, ehrlich tumour | A transplantable, poorly differentiated malignant tumour which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. (12 Dec 1998) |
| carcinoma, endometrioid | Ovarian carcinoma which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage. (12 Dec 1998) |
| carcinoma ex pleomorphic adenoma | <tumour> Carcinoma arising in a benign mixed tumour of a salivary gland, characterised by rapid enlargement and pain. (05 Mar 2000) |
| carcinoma, giant cell | An epithelial neoplasm characterised by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (12 Dec 1998) |