| granulocytic leukaemia | <haematology, tumour> A form of leukaemia characterised by an uncontrolled proliferation of myelopoietic cells in the bone marrow and in extramedullary sites, and the presence of large numbers of immature and mature granulocytic forms in various tissues (and organs) and in the circulating blood. The total count may range from 1000 (aleukaemic variety) to several hundred thousand per cu mm. The predominant cell is usually of the neutrophilic series, but, in a few instances, eosinophilic or basophilic granulocytes, or even megakaryocytes, may represent the chief form; early in granulocytic leukaemia, the circulating blood may contain excessive numbers of all of the granulocytic forms. Synonym: leukaemic myelosis, myelocytic leukaemia, myelogenic leukaemia, myelogenous leukaemia, myeloid leukaemia. (05 Mar 2000) |
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| granulocytic sarcoma | <tumour> A malignant tumour of immature myeloid cells, frequently subperiosteal, associated with or preceding granulocytic leukaemia. See: chloroma. Synonym: myeloid sarcoma. (05 Mar 2000) |
| granulocytic series | <haematology> The cells in the several stages of development in the bone marrow leading to the mature granulocyte of the circulation, e.g., myeloblasts, different stages of the myelocyte, granulocytes. (05 Mar 2000) |
| granulocytopenia | <haematology> A reduced number of white blood cells in the circulation. (18 Nov 1997) |
| granulocytopoiesis | <haematology> The production of granulocytes in the bone marrow. (18 Nov 1997) |
| granulocytopoietic | Pertaining to granulopoiesis. Synonym: granulocytopoietic. (05 Mar 2000) |
| granulocytosis | <haematology> A condition characterised by more than the normal number of granulocytes in the circulating blood or in the tissues. (05 Mar 2000) |
| granuloma | <pathology> Chronic inflammatory lesion characterised by large numbers of cells of various types (macrophages, lymphocytes, fibroblasts, giant cells), some degrading and some repairing the tissues. (18 Nov 1997) |
| granuloma annulare | <dermatology> Benign granulomatous disease of unknown aetiology characterised by a ring of localised or disseminated papules or nodules on the skin and palisading histiocytes surrounding necrobiotic tissue resulting from altered collagen structures. (12 Dec 1998) |
| granuloma endemicum | <dermatology, infectious disease> The lesion occurring in cutaneous leishmaniasis. (05 Mar 2000) |
| granuloma faciale | <dermatology> Persistent well-demarcated nodules that usually appear on the face and consist of a dense dermal infiltrate of eosinophils and neutrophils, separated from the epidermis and hair follicles, with fibrinoid vasculitis. (05 Mar 2000) |
| granuloma gangrenescens | Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases. An obsolete term for polymorphic reticulosis. Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma. (05 Mar 2000) |
| granuloma gravidarum | A pyogenic granuloma developing on the gingiva during pregnancy; thought to be related to hormonally altered response of the oral mucous membranes to local irritants such as bacterial plaque on adjacent teeth. Synonym: pregnancy tumour. (05 Mar 2000) |
| granuloma inguinale | <disease, microbiology> A rare sexually transmitted disease that is caused by Calymmatobacterium granulomatis. This infection is more common in the tropical and subtropical areas such as India, Guyana and new Guinea. There are approximately 100 cases reported annually in the United States. Men are affected more often than women. It is thought to be most commonly acquired through anal intercourse. Symptoms include a small red nodule on the genitalia that may form elevated masses of reddened tissue (granulation tissue). The lesions gradual spread and destroy genital tissue. Diagnosis is via tissue biopsy or culture. Treatment includes antibiotics. (27 Sep 1997) |
| granuloma inguinale tropicum | An elongated ulcer, with elevated papillary edges, sometimes occurring in the groin in persons in the tropics. Synonym: groin ulcer. (05 Mar 2000) |