| far Western analysis | Yeast gene, induced by factor, that causes cells to arrest in G1 phase, by interacting with the G1 cyclin, CLN2. (18 Nov 1997) |
|---|---|
| zoo blot analysis | A procedure using Southern blot analysis to test the ability of a nucleic acid probe from one species to hybridise with the DNA fragment of another species. (05 Mar 2000) |
| FISH Analysis | <molecular biology, technique> Use of a DNA or RNA probe todetect the presence of the complementaryDNA sequence in cloned bacterial or cultured eukaryotic cells.Also used for locating geneson chromosomes. The process is: Prepare microscope slide with cells in metaphase of mitosis, Treat slide with a weak base. Thus denaturing the DNA. Pour radioactively labelled probe onto the slide. Expose slide to photographic emulsion for a few days or weeks. Develop emulsion. (13 Oct 1997) |
| flow injection analysis | The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device. (12 Dec 1998) |
| fluctuation analysis | Method used to determine (for example) how many ion channels contribute to the transmembrane current. On the assumption that each channel is either open or shut, the noise in the recorded current can be considered to arise from the statistical fluctuation in the number of channels open and the magnitude of the fluctuation gives an estimate of the conductance of a single channel. (18 Nov 1997) |
| fourier analysis | Analysis based on the mathematical function first formulated by jean-baptiste-joseph fourier in 1807. The function, known as the fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the X-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerised tomography imaging, etc. (12 Dec 1998) |
| frequency analysis | <ecology, statistics> A method of evaluating vegetation in an area by establishing a transect and counting the occurrences of plant species at various sampling points along the transect. (07 Apr 1998) |
| least-squares analysis | A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model. (12 Dec 1998) |
| linkage analysis | <genetics> Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing. (12 Dec 1998) |
| allelic gene | See: allele, dominance of traits. (05 Mar 2000) |
| antibiotic resistance gene | Genes in a microorganism which confer resistance to antibiotics, for example by coding for enzymes which destroy it, by coding for surface proteins which prevent it from entering the microorganism, or by being a mutant form of the antibiotic's target so that it can ignore it. (09 Oct 1997) |
| autosomal gene | A gene located on any chromosome other than the sex chromosomes (X or Y). (05 Mar 2000) |
| bicoid gene | A group of genes which are important to the proper development of the head and thorax in the embryo of the fruit fly Drosophila melanogaster. (09 Oct 1997) |
| BRCA1 breast cancer susceptibility gene | This mutated (changed) version of the BRCA1 gene makes a person susceptible to developing breast cancer. (12 Dec 1998) |
| calcitonin gene-related peptide | <protein> A second product transcribed from the calcitonin gene. Calcitonin gene related peptide is found in a number of tissues including nervous tissue. It is a vasodilator that may participate in the cutaneous triple response. It is a neuropeptide of 37 amino acids with structural homology to salmon calcitonin. Co-localises with substance P in neurons. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. Intracerebral administration leads to a rise in noradrenergic sympathetic outflow, a rise in blood pressure and a fall in gastric secretion. Acronym: CGRP (05 May 2002) |