| gamma-glutamylcyclotransferase | <enzyme> An enzyme that catalyses the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. Chemical name: (5-L-Glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing) Registry number: EC 2.3.2.4 (12 Dec 1998) |
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| gamma-glutamylcysteine | A necessary precursor in the biosynthesis of glutathione; contains an isopeptide rather than a eupeptide bond. Gamma-glutamylcysteine synthetase, an enzyme that catalyses the first step in glutathione biosynthesis, reacting l-glutamate, l-cysteine, and ATP to form gamma-glutamylcysteine, ADP, and orthophosphate; inhibited by thiols such as glutathione. (05 Mar 2000) |
| gamma-glutamyl dipeptidase | <enzyme> Removes glycine from leukotriene d4 to form leukotriene e4 Registry number: EC 3.4.13.- (26 Jun 1999) |
| gamma-glutamylhistamine synthetase | <enzyme> Incorporates histamine or other amines into peptide linkage with glutamate; from aplysia ganglia Registry number: EC 6.3.2.- Synonym: gamma-gha synthetase, gamma-glutamyl amine synthetase, gamma-glutamyl octopamine synthetase, gamma-glutamyl tyramine synthetase (26 Jun 1999) |
| gamma-glutamyl hydrolase | N-Pteroyl-l-glutamate hydrolase;an enzyme cleaving l-glutamyl residues from pteridine oligoglutamates; used in certain antitumour treatments. Synonym: carboxypeptidase G, conjugase, gamma-glutamate (glutamate gamma-) carboxypeptidase. (05 Mar 2000) |
| gamma-glutamyltransferase | <enzyme> An enzyme that catalyses reversibly the transfer of a glutamyl group from a glutamyl-peptide and an amino acid to a peptide and a glutamyl-amino acid. It is often elevated above normal in hepatitis and other conditions that cause chemical liver damage. Chemical name: (5-L-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Registry number: EC 2.3.2.2 Acronym: GGT (12 Sep 2002) |
| gamma-glutamyl transpeptidase | <enzyme> An enzyme that catalyses reversibly the transfer of a glutamyl group from a glutamyl-peptide and an amino acid to a peptide and a glutamyl-amino acid. It is often elevated above normal in hepatitis and other conditions that cause chemical liver damage. Chemical name: (5-L-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Registry number: EC 2.3.2.2 Acronym: GGT (12 Sep 2002) |
| gamma-guanidinobutyraldehyde dehydrogenase | <enzyme> Nad and gamma-guanidinobutyraldehyde yields gamma-guanidinibutyrate and NADH Registry number: EC 1.2.1.- (26 Jun 1999) |
| gamma-iodopropyleneglycol | An organic form of iodine which slowly liberates iodine in the body after oral administration. Used primarily as an expectorant/mucolytic. Synonym: 3-iodo-1,2-propanediol, gamma-iodopropyleneglycol. (05 Mar 2000) |
| gamma knife | <radiobiology> A special multi-source irradiation machine which focus a high intesity of irradiation on a small area: it is used as local therapy in especially brain tumours. This is investigational and is not part of the routine array of cancer treatments. (16 Dec 1997) |
| gamma-l-glutamyl-l-cysteinylglycine | <biochemistry> The tripeptide _ glutamylcysteinylglycine. It contains an unusual peptide linkage between the _ carboxyl group of the glutamate side chain and the amine group of cysteine. The concentration of glutathione in animal cells is _5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leucotriene synthesis. (18 Nov 1997) |
| gamma-linolenic acid | <chemical> (z,z,z)-6,9,12-octadecatrienoic acid. An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as pge1. Chemical name: 6,9,12-Octadecatrienoic acid, (Z,Z,Z)- (12 Dec 1998) |
| gamma motor neurons | The reflex arc consisting of small anterior horn cells and neuroma, their small fibres projecting to the intrafusal bundle producing its contraction, which initiates the afferent impulses that pass through the posterior root to the anterior horn cells, inducing a stretch reflex. Synonym: gamma motor neurons, gamma motor system, Granit's loop. (05 Mar 2000) |
| gamma motor system | The reflex arc consisting of small anterior horn cells and neuroma, their small fibres projecting to the intrafusal bundle producing its contraction, which initiates the afferent impulses that pass through the posterior root to the anterior horn cells, inducing a stretch reflex. Synonym: gamma motor neurons, gamma motor system, Granit's loop. (05 Mar 2000) |
| gamma-oxalomesaconate hydratase | <enzyme> From pseudomonas ochraceae; forms gamma-oxalocitramalate Registry number: EC 4.2.1.- Synonym: gom hydratase (26 Jun 1999) |