| S-adenosyl-L-methionine-2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase | <enzyme> Proposed pathway for final reaction in ubiquinone biosynthesis. Registry number: EC 2.1.1.- Synonym: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, ubig gene product, ubig protein (26 Jun 1999) |
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| pyribenzyl methyl sulfate | 2-(hydroxymethyl)-1,1-dimethylpiperidinium methyl sulfate benzylate;an anticholinergic agent. Synonym: pyribenzyl methyl sulfate. (05 Mar 2000) |
| NADH-methyl viologen reductase | <enzyme> Fad-protein from rhodospirillum rubrum which also reduces methylene blue and 2,6-dichlorophenol-indophenol Registry number: EC 1.6.- (26 Jun 1999) |
| n-methyl-3,4-methylenedioxyamphetamine | <chemical> An n-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as mdma or ecstasy. Pharmacological action: adrenergic uptake inhibitors, hallucinogens, serotonin agents. Chemical name: 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl- (12 Dec 1998) |
| N methyl D aspartate receptor | <physiology> Glutamate receptor sub type (see excitatory amino acids). N methyl D aspartate receptor channels seem to be potentiated by intracellular arachidonic acid. Acronym: NMDA (26 Mar 1998) |
| N-methyl, D-aspartic acid | n methyl D aspartate receptor |
| 1-methyl-3-isobutylxanthine | <chemical> 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-2,6-dione. A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates cyclic nucleotide-dependent protein kinases. Pharmacological action: phosphodiesterase inhibitors. Chemical name: 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- (12 Dec 1998) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | <chemical> 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine. A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in parkinson disease. These toxic effects can be prevented by the administration of selective monoamine oxidase inhibitors. Since the cellular toxicity of the compound is similar to that observed in idiopathic parkinson disease, experimental studies with this compound can suggest new opportunities for effective therapy. The compound also induces duodenal ulcers. Pharmacological action: dopamine agents. Chemical name: Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl- (12 Dec 1998) |
| 1-methyl-4-phenylpyridinium | <chemical> 1-methyl-4-phenylpyridinium (mpp+). An active neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to paraquat, has also been used as an herbicide. Pharmacological action: dopamine agents, herbicides. Chemical name: Pyridinium, 1-methyl-4-phenyl- (12 Dec 1998) |
| 2-methyl branched-chain enoyl-CoA reductase | <enzyme> Important in the reversal of beta-oxidation under anaerobic conditions in ascaris suum Registry number: EC 1.3.1.52 Synonym: 2-methyl bce-CoA reductase (26 Jun 1999) |
| 3-(2,4--dioxo-6-methyl-5-pyrimidinyl)acrylic acid synthase | <enzyme> Involved in sparsomycin biosynthesis; catalyses conversion of 3-(4-oxo-6-methyl-5-pyrimidinyl)acrylic acid to 3-(2,4-dioxo-6-methyl-5-pyrimidinyl)acrylic acid Registry number: EC 1.14.13.- Synonym: (e)-uca synthase (26 Jun 1999) |
| (3-(5-methyl-2-thienyl)acryloyl)chymotrypsin | Pharmacological action: indicator and reagent Synonym: 3-mtac (26 Jun 1999) |
| 3-methyl-2-oxobutanoate hydroxymethyltransferase | <enzyme> Methylenetetrahydrofolate and alpha-ketoisovalerate gives tetrahydrofolate and ketopantoate Chemical name: 5,10-methylenetetrahydrofolate alpha-ketoisovalerate hydroxymethyltransferase Registry number: EC 2.1.2.11 Synonym: iphm transferase, panb protein, ketopantoate hydroxymethyltransferase (26 Jun 1999) |
| 3-O-methyl-fluorescein phosphatase | <enzyme> Used for assay of na-k-atpase in intact tissues Registry number: EC 3.6.1.- Synonym: 3-o-methylfluorescein phosphatase (26 Jun 1999) |
| (4-fluorophenyl)-alpha-methyl-5-benzoxazole methylamine | Amine derivative of flunoxaprofen. Pharmacological action: fluorescent dye Synonym: s-flopa (26 Jun 1999) |