| keratoderma, palmoplantar, diffuse | An autosomal dominant disorder characterised by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (keratoderma, palmoplantar), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present. (12 Dec 1998) |
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| leishmaniasis, diffuse cutaneous | A form of leishmaniasis, cutaneous caused by leishmania aethiopica in ethiopia and kenya, l. Pifanoi in venezuela, l. Braziliensis in south america, and l. Mexicana in central america. This disease is characterised by massive dissemination of skin lesions without visceral involvement. (12 Dec 1998) |
| leukodystrophy with diffuse Rosenthal fibre formation | A metabolic disorder whose onset can be in infancy, adolescence, or adulthood; characterised pathologically by widespread cerebral demyelination with astrocyte and primitive oligodendroglial cell proliferation; refractile Rosenthal fibres result from the degeneration of these proliferating cells; aetiology unknown, but possibly due to a metabolic defect of astrocytes; sex-linked recessive disorder. (05 Mar 2000) |
| benign lymphoma of the rectum | A rectal polyp composed of lymphoid tissue with follicle formation, covered by mucosa. (05 Mar 2000) |
| burkitt lymphoma | A form of undifferentiated malignant lymphoma usually found in central africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumour in virtually all cases of burkitt lymphoma. The epstein-barr virus (herpes virus 4, human) has been isolated from burkitt lymphoma cases in africa and it is implicated as the causative agent in these cases; however, most non-african cases are ebv-negative. (12 Dec 1998) |
| Burkitt's lymphoma | <oncology, tumour> A type of Non-Hodgkin lymphoma that most often occurs in young people between the ages of 12 and 30. The disease usually causes a rapidly growing tumour in the abdomen. (12 May 1997) |
| cancer, lymphoma, hodgkin's | A type of lymphoma (cancer of the lymphatic system). The most common symptom of Hodgkin's disease is a painless swelling in the lymph nodes in the neck, underarm, or groin. Hodgkin's disease is diagnosed when abnormal tissue is detected by a pathologist after a biopsy of an enlarged lymph node. Treatment usually includes radiation therapy or chemotherapy. Regular follow-up examinations are important after treatment for Hodgkin's disease. Patients treated for Hodgkin's disease have an increased risk of developing other types of cancer later in life, especially leukaemia. (12 Dec 1998) |
| cancer, lymphoma, non-hodgkin's | A lymphoma is a cancer that develops in the lymphatic system. The most common symptom of non-Hodgkin's lymphomas is a painless swelling in the lymph nodes in the neck, underarm, or groin. Non-Hodgkin's lymphomas are diagnosed with a biopsy of an enlarged lymph node. Follow-up examinations are important after lymphoma treatment. Most relapses occur in the first 2 years after therapy. (12 Dec 1998) |
| canine malignant lymphoma | <tumour> A progressive fatal disease of dogs characterised by neoplastic transformation and proliferation of lymphoid cells, usually originating in solid lymphoid organs (lymphosarcoma) or bone marrow (lymphocytic leukaemia). (05 Mar 2000) |
| malignant lymphoma | <tumour> A general term for ordinarily malignant neoplasms of lymphoid and reticuloendothelial tissues which present as apparently circumscribed solid tumours composed of cells that appear primitive or resemble lymphocytes, plasma cells, or histiocytes. Lymphomas appear most frequently in lymph nodes, spleen, or other normal sites of lymphoreticular cells; when disseminated, Lymphoma's, especially of the lymphocytic type, may invade the peripheral blood and manifest as leukaemia. Lymphomas are classified by cell type, degrees of differentiation, and nodular or diffuse pattern; Hodgkin's disease and Burkitt's lymphoma are special forms. (05 Mar 2000) |
| Mediterranean lymphoma | A spectrum of conditions ranging from a benign plasma cell hyperplasia to a highly malignant lymphoma of the small intestine. (12 Dec 1998) |
| well-differentiated lymphocytic lymphoma | <tumour> Essentially the same disease as chronic lymphocytic leukaemia, except that lymphocytes are not increased in the peripheral blood; lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes. Synonym: small lymphocytic lymphoma. (05 Mar 2000) |
| poorly differentiated lymphocytic lymphoma | <tumour> A B-cell lymphoma with nodular or diffuse lymph node or bone marrow involvement by large lymphoid cells. Synonym: follicular predominantly small cleaved cell lymphoma, nodular histiocytic lymphoma. (05 Mar 2000) |
| histiocytic lymphoma | <tumour> A malignant tumour of reticular tissue composed predominantly of neoplastic histiocytes. See: large cell lymphoma. (05 Mar 2000) |
| Hodgkin's lymphoma | <haematology, oncology> A human malgnant disorder of lymph tissue (lymphoma) that appears to originate in a particular lymph node and later spreads to the spleen, liver and bone marrow. It occurs mostly in individuals between the ages of 15 and 35. It is characterised by progressive, painless enlargement of the lymph nodes, spleen and general lymph tissue. Giant cells, the Reed Sternberg cells, with mirror image nuclei are diagnostic. Immunological depletion, caused perhaps by the excessive growth of neoplastic histiocytes, occurs. Four types of the disease are recognised depending on the relative predominance of various neoplastic derivatives of the lymphoid series. Pyrexia is often a feature of the disease. Death often results from generalised immunological inability to respond to infections. If detected early, it has a high remission rate. Staging: Ann Arbor classification; each stage is further classified as:, A no symptoms, B fever, sweats, weight loss. Stage I - involvement of a single lymph-node region or extralymphatic site. Stage II - two or more sites of involvement on the same side of the diaphragm. Stage III - disease involvement on both sides of the diaphragm. Stage IV - disseminated disease of extralymphatic organs, with or without lymph-node involvement. Indicence: approximately 1,500 new cases per year in the UK. (30 Mar 2000) |