| cell transformation, neoplastic | Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. (12 Dec 1998) |
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| cell transformation, viral | An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. (12 Dec 1998) |
| cell transplantation | Transference of cells within an individual, between individuals of the same species, or between individuals of different species. (12 Dec 1998) |
| cell wall | 1. <cell biology> Extracellular material serving a structural role. 2. <plant biology> In plants the primary wall is pectin rich, the secondary wall mostly composed of cellulose. 3. <microbiology> In bacteria, cell wall structure is complex: the walls of gram-positive and gram-negative bacteria are distinctly different. Removal of the wall leaves a protoplast or spheroplast. (07 Apr 1998) |
| cell wall skeleton | <chemical> A mucoprotein found in the cell wall of various types of bacteria. It has adjuvant and antitumour activities and has been used to augment the production of lymphokine-activated killer (lak) cells. Pharmacological action: adjuvants, immunologic. (12 Dec 1998) |
| cell-bound antibody | A term used for antibody on the surface of cells that may be bound either through antigen combining sites or other sites such as the Fc region. (05 Mar 2000) |
| cell-free extract | <cell culture> A liquid that is a mixture of the contents of a particular type of cell, sometimes the organelles are also filtered out of the liquid. (26 Mar 1998) |
| cell-free protein synthesis | <technique> An in vitro method to make proteins, using amino acids, the mRNA corresponding to the protein to be made, and a cell-free extract (the contents of a cell after removal of the cell wall and/or outer cell membranes) for other needed components and enzymes. (26 Mar 1998) |
| cell-free system | <cell culture, molecular biology> Any system in which a normal cellular reaction is reconstituted in the absence of cells for example in vitro translation systems that will synthesise protein from mRNA using a lysate of rabbit reticulocytes or wheat germ. A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (12 Dec 1998) |
| cell-mediated immunity | <immunology> Immune response that involves effector T lymphocytes and not the production of humoral antibody. Responsible for allograft rejection, delayed hypersensitivity and in defence against viral infection and intracellular protozoan parasites. (26 Mar 1998) |
| cell-mediated reaction | Immunological reaction of the delayed type, involving chiefly T lymphocytes, important in host defense against infection, in autoimmune diseases, and in transplant rejection. See: skin test. (05 Mar 2000) |
| cella | A room or cell. Origin: L. Storeroom, or compartment (05 Mar 2000) |
| cella media | The body of the lateral ventricle of the brain, extending from the interventricular foramen (of Monro) to the collateral trigone (i.e., junction of posterior and inferior horns). Synonym: cella media. (05 Mar 2000) |
| cellicolous | Living within cells. Origin: L. Cella, cells, + colo, to abide in (05 Mar 2000) |
| cellobiase | A glucohydrolase similar to alpha-d-glucosidase, but attacking beta-glucosides and releasing beta-d-glucose. Synonym: amygdalase, cellobiase, gentiobiase. (05 Mar 2000) |
| B-cell leukaemia | A test which detects the presence of antigens on the surface of B lymphocytes. These antigens can indicate the presence of leukaemia. most often this is used to detect and differentiate chronic lymphocytic leukaemia from acute lymphocytic leukaemia. Origin: Gr. Haima = blood (27 Sep 1997) |
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| B-cell stimulatory factor 2 | <cytokine> A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate. An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow. Acronym: IL-6 (12 Dec 1998) |
| beaker cell | 1. <pathology> Cell of the epithelial lining of small intestine that secretes mucus and has a very well developed Golgi apparatus. 2. <zoology> Cell type characteristic of larval lepidopteran midgut, containing a potent H ATPase and thought to be involved in maintenance of ion and pH gradients. (10 Oct 1997) |
| Beale's cell | A bipolar ganglion cell of the heart with one spiral and one straight prolongation. (05 Mar 2000) |
| berry cell | A crenated red blood cell with surface spicules. (05 Mar 2000) |
| beta cell | 1. <pathology> Cells of the pancreas within discrete endocrine islands (Islets of Langerhans) embedded in the major exocrine tissue of vertebrate pancreas. The B or beta cells (originally distinguished by differential staining from A, C and D), are responsible for synthesis and secretion of insulin, a hormone that controls the level of glucosein the blood. 2. Also refers to the beta cells of the anterior lobe of hypophysis. These are a population of functionally diverse cell's that contain basophilic granules and secrete hormones such as ACTH, lipotropin, thyrotropin, and the gonadotropins. Synonym: basophil cell of anterior lobe of hypophysis. (05 Mar 2000) |
| beta-cell src-homology tyrosine kinase | <enzyme> A murine frk (fyn-related kinase) homolog; genbank l36132; do not confuse with brain-specific kinase bsk Registry number: EC 2.7.1.- Synonym: beta-cell sh tk, bsk protein, sh tk, bsk gene product, sh tk (26 Jun 1999) |
| betz cell | Large pyramidal cells in the motor cortex of the precentral gyrus of the motor cortex. (27 Sep 1997) |
| BHK cell | <cell culture> A quasi diploid established line of Syrian hamster cells, descended from a clone (Clone 13) isolated by Stoker and McPherson from an unusually rapidly growing primary culture of new born hamster kidney tissue. Usually described as fibroblastic, although smooth muscle like in that they express the muscle intermediate filament protein desmin. Widely used as a viral host, in studies of oncogenic transformation and of cell physiology. (18 Nov 1997) |
| bipolar cell | <cell biology, physiology> A class of retinal interneurons, named after their morphology, that receive input from the photoreceptors and send it to the ganglion cells. Bipolar cells are nonspiking, their response to light is evenly graded and shows lateral inhibition. (19 Jan 1998) |
| blast cell | <haematology> A immature cell of a proliferative compartment in a cell lineage that normally represent up to 5% of the cells in the bone marrow. An over-production of blasts in the marrow is characteristic of leukaemia when the blast cells often spill out into the blood stream. (17 Mar 1998) |
| blood cell | <haematology> There are three main types of cell in the blood stream. The red cell, which carries oxygen, the white cell, which fights infections and the platelet, which helps prevent bleeding. The correct balance between each cell type must be maintained for the body to remain healthy. (13 Nov 1997) |
| blood cell count | A count of the number of leukocytes and erythrocytes per unit volume in a sample of venous blood. A complete blood count (cbc) also includes measurement of the haemoglobin, haematocrit, and erythrocyte indices. (12 Dec 1998) |
| bone cell | <pathology> Osteoblast that is embedded in bony tissue and which is relatively inactive. (18 Nov 1997) |
| bottle cell | <embryology> The first cells to migrate inwards at the blastopore during amphibian gastrulation. The neck of the bottle is at the outer surface of the embryo. (18 Nov 1997) |