| amino-terminal | <biochemistry> The end of a protein or polypeptide chain with the unattached amino group or the aminoacyl residue containing it. Each amino acid in the chain has an amino group on one side, which is attached to the carboxyl group (COOH group) of the previous amino acid, and a carboxyl group on the other side (which is attached to the amino group of the next amino acid). The other end of the polypeptide chain is called the carboxyl terminal. Synonym: NH2-terminal. (14 Aug 2000) |
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| amino-terminal residue | <biochemistry> The only amino acid residue in a polypeptide chain that has a free alpha-amino group, it defines the amino terminus of the polypeptide. (09 Oct 1997) |
| RNA, transfer, amino acyl | Intermediates in protein biosynthesis. The compounds are formed from amino acids, ATP and transfer RNA, a reaction catalyzed by aminoacyl trna synthetase. They are key compounds in the genetic translation process. (12 Dec 1998) |
| c-Jun amino-terminal kinase | <enzyme> A stress-activated protein kinase; 46-kD kinase that phosphorylates ser(63) and ser(73) of c-jun; similar to yeast hog1 kinase; amino acid sequence given in second source; genbank l23118 Registry number: EC 2.7.10.- Synonym: jn kinase, jnk1 protein kinase, jnk-46, jnk1 protein, jun-nh2-terminal kinase, stress-activated protein kinase 1, sap kinase-1, sapk1, p46 sap kinase, c-jun kinase-1 (26 Jun 1999) |
| N-(5'-phosphoribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase | <enzyme> Has beta/alpha-barrel fold structure; involved in biosynthesis of histidine Registry number: EC 5.3.1.16 Synonym: hisa gene product, pfacr isomerase, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (26 Jun 1999) |
| succinylalanyl-alanyl-prolyl-phenylalanyl-7-amino-4-methylcoumarin hydrolase | <enzyme> Enzyme may be involved in attainment of transformed state Registry number: EC 3.4.24.- Synonym: suc-ala-ala-pro-phe-amc hydrolase, saapp-amc-hydrolase (26 Jun 1999) |
| essential amino acids | Alpha-amino acids nutritionally required by an organism and which must be supplied in its diet (i.e., cannot be synthesised by the organism) either as free amino acid or in proteins. (05 Mar 2000) |
| excitatory amino acids | Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear. (12 Dec 1998) |
| 2-amino-2-deoxy-D-galactose | <chemical> Chemical name: D-Galactose, 2-amino-2-deoxy- (12 Dec 1998) |
| 2-amino-5-phosphonovalerate | <chemical> A potent and specific antagonist of nmda receptors (receptors, nmda) in the d-enantiomeric form. The l form is inactive at nmda receptors but may affect the ap4 (2-amino-4-phosphonobutyrate; apb) excitatory amino acid receptors. Pharmacological action: excitatory amino acid antagonists. Chemical name: Norvaline, 5-phosphono- (12 Dec 1998) |
| (3-(arginyl)amino-4-(4-nitrophenyl)butyryl)-leucyl-prolyl-threonine | Pharmacological action: neurotransmitters Synonym: 2-afb(p-no2)-proctolin, (afb(p-no2)(2))-proctolin (26 Jun 1999) |
| 8-amino-7-oxononanoate synthase | <enzyme> Chemical name: 7-keto-8-aminopelargonic acid synthetase Registry number: EC 2.3.1.47 Synonym: 7-kap synthetase, 8-amino-7-oxopelargonate synthase, 7-oxo-8-aminononanoate synthase, biof gene product (26 Jun 1999) |
| adaptive enzyme | Inducible enzyme, an enzyme that can be detected in a growing culture of a microorganism, after the addition of a particular substance (inducer) to the culture medium, but was not detectable prior to the addition and can act on the inducer. A prototype is the beta-galactosidase of Escherichia coli, synthesised upon the addition of various galactosides, whether or not these are good substrates. Compare: constitutive enzyme. Synonym: adaptive enzyme. (05 Mar 2000) |
| allosteric enzyme | <biochemistry, chemistry> A regulatory enzyme whose activity is modified by the noncovalent binding of a particular metabolite at a site (the allosteric site) other than the active site. (09 Oct 1997) |
| angiotensin-converting enzyme | <enzyme> This hydrolase enzyme cleaves the decapeptide angiotensin I (biologically inactive) to form active angiotensin II by angiotensin-converting enzyme which removes a dipeptide (histidylleucine) from angiotensin I. Angiotensin II causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands. Angiotensin is finally broken down by angiotensinases. Elevations in angiotensin converting enzyme are seen sarcoidosis, histoplasmosis, alcoholic cirrhosis, asbestosis, berylliosis, diabetes, Hodgkin's disease, hyperthyroidism, amyloidosis, primary biliary cirrhosis, idiopathic pulmonary fibrosis, pulmonary embolism, scleroderma, silicosis, tuberculosis, Gaucher's disease and leprosy. The normal values are 18 to 67 U/ml over 20 years of age (people under 20 have higher levels). Drugs that inhibit ACE are used to treat hypertension and congestive heart failure. See: angiotensin-converting enzyme inhibitor Acronym: ACE (12 Aug 2000) |