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polyketide synthase ketoreductase <enzyme> A component of the polyketide synthase; mapped by analogy with fatty acid synthetase complex.
Registry number: EC 1.1.-
Synonym: pks ketoreductase, actiii gene product
(26 Jun 1999)
myo-inositol-1-phosphate synthase <enzyme> An enzyme that catalyses the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD.
Chemical name: 1L-myo-Inositol-1-phosphate lyase (isomerizing)
Registry number: EC 5.5.1.4
(12 Dec 1998)
myrcene synthase <enzyme> Isolated from the grand fir abies grandis.
Registry number: EC 5.5.-
(26 Jun 1999)
porphobilinogen synthase <enzyme> An enzyme that catalyses the formation of porphobilinogen from two molecules of 5-aminolevulinic acid.
Chemical name: 5-Aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)
Registry number: EC 4.2.1.24
(12 Dec 1998)
porphobilinogen synthase porphyria An inherited disorder in which there is a deficiency of porphobilinogen synthase; d-aminolevulinate levels are elevated, leading to neurological disturbances.
Synonym: porphobilinogen synthase porphyria.
(05 Mar 2000)
precorrin-3 synthase <enzyme> One of enzymes involved in hydrogenobyrinic acid synthesis; methylates c-20 of precorrin-2 to form precorrin-3; 10 aa amino-terminal sequence given in first source
Registry number: EC 2.1.1.-
Synonym: cbil gene product, precorrin-2 20-methyltransferase
(26 Jun 1999)
cystathionine beta-synthase <enzyme> A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyses the reaction of homocysteine with serine to form cystathionine with the elimination of water.
Chemical name: L-Serine hydro-lyase (adding homocysteine)
Registry number: EC 4.2.1.22
(12 Dec 1998)
cystathionine gamma-synthase o-succinylhomoserine (thiol)-lyase
cysteine synthase <enzyme> An enzyme that catalyses the biosynthesis of cysteine in microorganisms and plants from o-acetyl-l-serine and hydrogen sulfide.
Chemical name: O(3)-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
Registry number: EC 4.2.99.8
(12 Dec 1998)
pristinamycin IIA synthase <enzyme> A heterodimer of snaa and snab proteins (snaa and snab gene products, respectively); catalyses the oxidation of piib to piia with fmnh2 and o2 as cofactors; from streptomyces pristinaespiralis.
Registry number: EC 1.3.99.-
Synonym: pii(a) synthase, piia synthase
(26 Jun 1999)
prostaglandin endoperoxide synthase <enzyme> An enzyme complex that catalyses the formation of prostaglandins from the appropriate unsaturated fatty acid, molecular oxygen, and a reduced acceptor.
See: cyclooxygenase
Chemical name: (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Registry number: EC 1.14.99.1
(12 Dec 1998)
prostaglandin-E synthase <enzyme> Converts pgh to pge; part of prostaglandin synthase complex
Registry number: EC 5.3.99.3
Synonym: prostaglandin r2 e-isomerase, endoperoxide isomerase, prostaglandin endoperoxide e isomerase, prostaglandin h2 e-isomerase, pge2 isomerase, prostaglandin e2 isomerase, pgr2 e-isomerase, prostaglandin h2-prostaglandin e2 isomerase, prostaglandin e isomerase
(26 Jun 1999)
prostaglandin-F synthase <enzyme> Catalyses conversion of pgd2 to pgf2alpha; also converts pgh2 to pgf2alpha
Registry number: EC 1.1.1.188
Synonym: pgd2 11-keto reductase, pgf synthetase, pgf synthase, prostaglandin d2-NADPH-dependent ketoreductase, prostaglandin f synthetase, pgf2alpha synthase, prostaglandin d2 11-keto reductase
(26 Jun 1999)
pseudouridine 746-32 synthase <enzyme> A dual-specificity pseudouridine synthase; forms both pseudouridine 746 in e. Coli 23s ribosomal RNA and pseudouridine 32 in trna(phe); has 219 aa; mw 24 kD
Registry number: EC 5.4.99.-
Synonym: 23s RNA pseudouridine 746 synthase, psi746 synthase, trna(phe) pseudouridine 32 synthase, psi32 synthase
(26 Jun 1999)
psoralen synthase <enzyme> Nadph-dependent cytochrome p-450 monooxygenase which converts (+) marmesin by initial hydroxylation at c3', followed by release of water, acetone and psoralen
Registry number: EC 1.14.13.-
Synonym: psoralen 5-monooxygenase
(26 Jun 1999)
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